K
Karthik Anantharaman
Researcher at University of Wisconsin-Madison
Publications - 105
Citations - 8645
Karthik Anantharaman is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Metagenomics & Biology. The author has an hindex of 32, co-authored 81 publications receiving 5857 citations. Previous affiliations of Karthik Anantharaman include University of Michigan & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
A new view of the tree of life
Laura A. Hug,Laura A. Hug,Brett J. Baker,Karthik Anantharaman,Christopher T. Brown,Alexander J. Probst,Cindy J. Castelle,Cristina N. Butterfield,Alex W Hernsdorf,Yuki Amano,Kotaro Ise,Yohey Suzuki,Natasha Dudek,David A. Relman,David A. Relman,Kari M. Finstad,Ronald Amundson,Brian C. Thomas,Jillian F. Banfield,Jillian F. Banfield +19 more
TL;DR: New genomic data from over 1,000 uncultivated and little known organisms, together with published sequences, are used to infer a dramatically expanded version of the tree of life, with Bacteria, Archaea and Eukarya included.
Journal ArticleDOI
Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system
Karthik Anantharaman,Christopher T. Brown,Laura A. Hug,Itai Sharon,Cindy J. Castelle,Alexander J. Probst,Brian C. Thomas,Andrea Singh,Michael J. Wilkins,Ulas Karaoz,Eoin L. Brodie,Kenneth H. Williams,Susan S. Hubbard,Jillian F. Banfield,Jillian F. Banfield +14 more
TL;DR: Terabase-scale cultivation-independent metagenomics is applied to aquifer sediments and groundwater and 2,540 draft-quality, near-complete and complete strain-resolved genomes are reconstructed, finding that few organisms within the community can conduct multiple sequential redox transformations.
Journal ArticleDOI
Asgard archaea illuminate the origin of eukaryotic cellular complexity
Katarzyna Zaremba-Niedzwiedzka,Eva F. Caceres,Jimmy H. Saw,Disa Bäckström,Lina Juzokaite,Emmelien Vancaester,Kiley W. Seitz,Karthik Anantharaman,Piotr Starnawski,Kasper Urup Kjeldsen,Matthew B. Stott,Takuro Nunoura,Jillian F. Banfield,Andreas Schramm,Brett J. Baker,Anja Spang,Thijs J. G. Ettema +16 more
TL;DR: The results expand the known repertoire of ‘eukaryote-specific’ proteins in Archaea, indicating that the archaeal host cell already contained many key components that govern eukaryotic cellular complexity.
Journal ArticleDOI
New CRISPR–Cas systems from uncultivated microbes
David Burstein,Lucas B. Harrington,Steven C. Strutt,Alexander J. Probst,Karthik Anantharaman,Brian C. Thomas,Jennifer A. Doudna,Jillian F. Banfield +7 more
TL;DR: A number of CRISPR–Cas systems, including the first reported Cas9 in the archaeal domain of life, are identified using genome-resolved metagenomics, enabling validation of robust in vivo RNA-guided DNA interference activity in Escherichia coli.
Journal ArticleDOI
VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences.
TL;DR: VIBRANT is the first method to utilize a hybrid machine learning and protein similarity approach that is not reliant on sequence features for automated recovery and annotation of viruses, determination of genome quality and completeness, and characterization of viral community function from metagenomic assemblies.