Author
Karumanchi V. Rao
Bio: Karumanchi V. Rao is an academic researcher from University of Mississippi. The author has contributed to research in topics: Triterpene & Lignan. The author has an hindex of 1, co-authored 1 publications receiving 42 citations.
Topics: Triterpene, Lignan, Vitex altissima
Papers
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TL;DR: A new tetrahydrofuranoid lignan, altissinone and a new acylated flavone C-glucoside, 2''-O-p-hydroxybenzoylorientin were isolated in addition to several known triterpene acids and flavonoids from the ethyl acetate extractives of the leaves of Vitex altissima.
45 citations
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TL;DR: This review describes more than 600 new examples of naturally occurring flavonoids found either as aglycones or glycosides, comprising flavones, flavonols, chalcones, dihydrochalcones and anthocyanidins.
354 citations
TL;DR: This review covers the source, chemistry and bioactivities of natural lignans, and highlights the total syntheses of some lignan motifs and asymmetric synthese of their motifs.
201 citations
TL;DR: The future scope of Vitex species has been emphasized with a view to establish their multifarious biological activities and mode of action.
Abstract: The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Essential oils, flavonoids, iridoid glycosides, diterpenoides and ligans constitute major classes of phytoconstituents of the genus. A few species of this genus have medicinal value, among these, leaves and fruits of V. agnus-castus Linn. (Verbenaceae) has been traditionally used in treatment of women complaints. V. agnus-castus has also been included in herbal remedies, which are in clinical use to regulate the menstrual cycle, reduce premenstrual symptom tension and anxiety, treat some menopausal symptoms as well as to treat hormonally induced acne. Despite a long tradition of use of some species, the genus has not been explored properly. In the concluding part, the future scope of Vitex species has been emphasized with a view to establish their multifarious biological activities and mode of action.
105 citations
TL;DR: The early fourth instar larvae of Culex quinquefasciatus, reared in the laboratory were used for larvicidal assay with leaf extracts of Vitex negundo, ViteX trifolia,Vitex peduncularis and Vitez altissima, which possessed varying levels of larv suicidal nature.
Abstract: The early fourth instar larvae of Culex quinquefasciatus, reared in the laboratory were used for larvicidal assay with leaf extracts of Vitex negundo, Vitex trifolia, Vitex peduncularis and Vitex altissima. The methanol extracts of the four species possessed varying levels of larvicidal nature. The highest larvicidal activity was found with the extract of V. trifolia (LC50 = 41.41 ppm) followed by V. peduncularis (LC50 = 76.28 ppm), V. altissima (LC50 = 128.04 ppm) and V. negundo (LC50 = 212.57 ppm).
100 citations
TL;DR: Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triter penoids, 7-14, were isolated from the leaves of Vitex negundo var.
Abstract: Six new polyoxygenated triterpenoids, cannabifolins A–F (1–6), and eight known triterpenoids, 7–14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9–40.5 μM.
45 citations