Katharina Kronenberg

TL;DR: It is concluded that IFNγ-MdC represent macrophages in a novel state of activation, possessing multiple T cell-suppressive effects with therapeutic potential for the treatment of autoimmune inflammation.

TL;DR: In this article, the authors identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4+ T cells (TEM cells).

TL;DR: Patients with chronic HCV infection were comprehensively monitored by flow cytometry to identify pretreatment immunological variables that predicted HCV RNA negativity within 4 weeks of commencing DAA treatment, and non-specific, systemic CD8+ T cell activation predicted a longer time to viral clearance.

TL;DR: Externally validate the performance of 59 previously reported markers of irAE risk in a new cohort of 110 patients receiving Nivolumab and Ipilimumab therapy, finding that alone or combined, the discriminatory value of these routine clinical parameters and flow cytometry biomarkers was poor.

TL;DR: In this article, a 10-color flow cytometry panel was developed and validated for reliably quantifying CD4+ TEM cells and other biomarkers of irAE risk in peripheral blood samples.