K
Katharina Schmidt-Bleek
Researcher at Charité
Publications - 98
Citations - 5100
Katharina Schmidt-Bleek is an academic researcher from Charité. The author has contributed to research in topics: Bone healing & Bone regeneration. The author has an hindex of 33, co-authored 85 publications receiving 3793 citations. Previous affiliations of Katharina Schmidt-Bleek include Humboldt University of Berlin & Free University of Berlin.
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Journal ArticleDOI
Macrophages in bone fracture healing: Their essential role in endochondral ossification.
Claudia Schlundt,Thaqif El Khassawna,Alessandro Serra,Anke Dienelt,Sebastian Wendler,Hanna Schell,Nico van Rooijen,Andreas Radbruch,Richard Lucius,Susanne Hartmann,Georg N. Duda,Katharina Schmidt-Bleek +11 more
TL;DR: Cumulative data illustrate their so far unreported highly important role in endochondral ossification and the necessity of a fine balance in M1/M2 macrophage function, which appears mandatory to fracture healing and successful regeneration.
Journal ArticleDOI
The Early Fracture Hematoma and Its Potential Role in Fracture Healing
Paula Kolar,Katharina Schmidt-Bleek,Hanna Schell,Timo Gaber,D. Toben,Gerhard Schmidmaier,Carsten Perka,Frank Buttgereit,Georg N. Duda +8 more
TL;DR: The regenerative fracture healing process and the close interplay between the skeletal and immune systems are summarized and a better understanding of immune reactions in the hematoma may have implications for bone tissue engineering strategies are discussed.
Journal ArticleDOI
A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.
TL;DR: This review aims to provide an overview on endogenous cascades of bone material formation and how these are transferred to new perspectives in biomaterial-driven approaches in bone regeneration.
Journal ArticleDOI
The need for transparency and good practices in the qPCR literature
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Carl T. Wittwer,Peter Schjerling,Philip J. R. Day,Mónica Abreu,Begoña Aguado,Jean-François Beaulieu,Anneleen Beckers,Sara Bogaert,John A. Browne,Fernando Carrasco-Ramiro,Liesbeth Ceelen,Kate L. Ciborowski,Pieter Cornillie,Stephanie Coulon,Ann Cuypers,Sara De Brouwer,Leentje De Ceuninck,Jurgen De Craene,Hélène De Naeyer,Ward De Spiegelaere,Kato Deckers,Annelies Dheedene,Kaat Durinck,Margarida Ferreira-Teixeira,Annelies Fieuw,Jack M. Gallup,Sandra Gonzalo-Flores,Karen Goossens,Femke Heindryckx,Elizabeth Herring,Hans Hoenicka,Laura Icardi,Rolf Jaggi,Farzad Javad,Michael Karampelias,Frederick S. B. Kibenge,Molly J. T. Kibenge,Candy Kumps,Irina Lambertz,Tim Lammens,Amelia Markey,Peter Messiaen,Evelien Mets,Sofia Morais,Alberto Mudarra-Rubio,Justine K. Nakiwala,Hilde Nelis,Pål A. Olsvik,Claudina Perez-Novo,Michelle Plusquin,Tony Remans,Ali Rihani,Paulo Rodrigues-Santos,Pieter Rondou,Rebecca Sanders,Katharina Schmidt-Bleek,Kerstin Skovgaard,Karen Smeets,Laura Tabera,Stefan Toegel,Tim Van Acker,Wim Van den Broeck,Joni Van der Meulen,Mireille Van Gele,Gert Van Peer,Mario Van Poucke,Nadine Van Roy,Sarah Vergult,Joris Wauman,Marina Tshuikina-Wiklander,Erik Willems,Sara Zaccara,Fjoralba Zeka,Jo Vandesompele +83 more
TL;DR: Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information.
Journal ArticleDOI
Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans
Simon Reinke,Sven Geissler,William R. Taylor,Katharina Schmidt-Bleek,Kerstin Juelke,Verena Schwachmeyer,Michael Dahne,Tony Hartwig,Levent Akyüz,Christian Meisel,Nadine Unterwalder,Navrag B. Singh,Petra Reinke,Norbert P. Haas,Hans-Dieter Volk,Georg N. Duda +15 more
TL;DR: The study revealed that delayed fracture healing significantly correlated with enhanced levels of terminally differentiated CD8+ effector memory T (TEMRA) cells (CD3+CD8+CD11a++CD28−CD57+ T cells) in peripheral blood.