Kathleen H. Burns

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: It is established that bidirectional communication between the oocyte and companion somatic cells is essential for development of an egg competent to undergo fertilization and embryogenesis and the challenge for the future is to identify the factors that participate in this communication and their mechanisms of action.

TL;DR: The fundamental properties of TEs and their complex interactions with their cellular environment are introduced, which are crucial to understanding their impact and manifold consequences for organismal biology.

TL;DR: The activity of transposable elements in human cancers, particularly long interspersed element-1 (LINE-1) is described, and their activity results in somatically acquired insertions in cancer genomes.

TL;DR: Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development and is isolated mammalian NPM2 orthologs to study chromatin remodeling in vivo.