Kathryn A. Martin

TL;DR: A scholarly review of the published literature on menopausal hormonal therapy (MHT), make scientifically valid assessments of the available data, and grade the level of evidence available for each clinically important endpoint to arrive at major conclusions.

TL;DR: The prevalence of gonadotropin abnormalities is very high in women with PCOS selected on purely clinical grounds, but is modified by recent spontaneous ovulation, and the positive relationship between LH pulse frequency and both pool LH and LH to FSH ratio supports the hypothesis that a rapid frequency of GnRH secretion may play a key etiologic role in the gonadotropic defect in PCOS patients.

TL;DR: The Task Force suggests testing for elevated androgen levels in women with moderate or severe hirsutism or hirsUTism of any degree when it is sudden in onset, rapidly progressive, or associated with other abnormalities such as menstrual dysfunction, obesity, or clitoromegaly.

TL;DR: How effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies is discussed, and the impact on modern hormone therapy protocols and pharmaceutical development is considered.

TL;DR: Evidence supporting various strategies is presented, followed by a review of formal guidelines, when they exist, and the article ends with the authors' clinical recommendations.