K
Katri Pajusola
Researcher at Ludwig Institute for Cancer Research
Publications - 44
Citations - 9206
Katri Pajusola is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Angiogenesis & Receptor tyrosine kinase. The author has an hindex of 30, co-authored 44 publications receiving 8991 citations. Previous affiliations of Katri Pajusola include Mount Sinai Hospital, Toronto & University of Zurich.
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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
Vladimir Joukov,Katri Pajusola,Arja Kaipainen,Dmitri Chilov,Isto Lahtinen,Eola Kukk,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
TL;DR: VEGF‐C is a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
Journal Article
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases (vol 15, pg 290, 1996)
Vladimir Joukov,Katri Pajusola,Arja Kaipainen,Dmitri Chilov,Isto Lahtinen,Eola Kukk,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
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Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
Daniel J. Dumont,Lotta Jussila,Jussi Taipale,Athina Lymboussaki,Tuija Mustonen,Katri Pajusola,Martin L. Breitman,Kari Alitalo +7 more
TL;DR: It is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos, indicating an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
Journal ArticleDOI
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Birgitta Olofsson,Katri Pajusola,Arja Kaipainen,G. von Euler,Vladimir Joukov,Olli Saksela,Arto Orpana,R F Pettersson,Kari Alitalo,Ulf Eriksson +9 more
TL;DR: The results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
Journal ArticleDOI
A model for gene therapy of human hereditary lymphedema
Marika J. Karkkainen,Anne Saaristo,Lotta Jussila,Kaisa Karila,Elizabeth C. Lawrence,Katri Pajusola,Hansruedi Büeler,Anne Eichmann,Risto A. Kauppinen,Mikko I. Kettunen,Seppo Ylä-Herttuala,David N. Finegold,Robert E. Ferrell,Kari Alitalo +13 more
TL;DR: By using virus-mediated VEGF-C gene therapy, the results suggest that growth factor gene therapy is applicable to human lymphedema and provide a paradigm for other diseases associated with mutant receptors.