K
Katrin Hayess
Researcher at Federal Institute for Risk Assessment
Publications - 11
Citations - 456
Katrin Hayess is an academic researcher from Federal Institute for Risk Assessment. The author has contributed to research in topics: Embryonic stem cell & Developmental toxicity. The author has an hindex of 9, co-authored 11 publications receiving 417 citations. Previous affiliations of Katrin Hayess include University of Potsdam.
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Journal ArticleDOI
Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy
Christian Geier,Katja Gehmlich,Elisabeth Ehler,Sabine Hassfeld,Andreas Perrot,Katrin Hayess,Nuno Cardim,Katrin Wenzel,Bettina Erdmann,Florian Krackhardt,Maximilian G. Posch,Karl Josef Osterziel,Angelika Bublak,Herbert Nägele,Thomas Scheffold,Rainer Dietz,Rainer Dietz,Kenneth R. Chien,Simone Spuler,Dieter O. Fürst,Peter Nürnberg,Cemil Özcelik,Cemil Özcelik +22 more
TL;DR: The results support the view that HCM is not exclusively a sarcomeric disease and also suggest that impaired mechano-sensory stress signalling might be involved in the pathogenesis of HCM.
Journal ArticleDOI
Dimerisation of myomesin: implications for the structure of the sarcomeric M-band.
Stephan Lange,Mirko Himmel,Daniel Auerbach,Irina Agarkova,Katrin Hayess,Dieter O. Fürst,Jean-Claude Perriard,Elisabeth Ehler,Elisabeth Ehler +8 more
TL;DR: The new and the already previously identified myomesin interaction sites are integrated into the first three-dimensional model of the sarcomeric M-band on a molecular basis and it is suggested that, similar to alpha-actinin in the Z-disc, theMyomesin dimers cross-link the contractile filaments in the M- band.
Journal ArticleDOI
Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro.
Anke Visan,Katrin Hayess,Dana Sittner,Elena E. Pohl,Elena E. Pohl,Christian Riebeling,Birgitta Slawik,Konrad Gulich,Michael Oelgeschläger,Andreas Luch,Andrea Seiler +10 more
TL;DR: The current study shows that D3 mESCs differentiate efficiently into neural cells involving a neurosphere-like state and that this system is suitable to detect adverse effects of neurodevelopmental toxicants.
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Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.
J. Otten,P.F.M. van der Ven,P.F.M. van der Ven,Padmanabhan Vakeel,Padmanabhan Vakeel,Stefan Eulitz,Gregor Kirfel,O. Brandau,M. Boesl,Jan W. Schrickel,Markus Linhart,Katrin Hayess,F. J. Naya,Hendrik Milting,Rainer Meyer,Dieter O. Fürst,Dieter O. Fürst +16 more
TL;DR: In this article, the function of Xin variants in the mammalian heart was investigated in mice deficient in all three Xin isoforms (XinAB−/− mice) and the results indicated that XinC may be involved in the development of human cardiac hypertrophy.
Journal ArticleDOI
Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain
Christian Riebeling,Katrin Hayess,Annelieke K. Peters,Margino Steemans,Horst Spielmann,Andreas Luch,Andrea Seiler +6 more
TL;DR: The EST performed well below the 78% accuracy expected from the validation study using a new set of chemicals and pharmaceutical compounds, and also of toxicity criteria, tested to enlarge the database of the validated EST.