Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity

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The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations.

Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms.

Absorption of Chlorogenic Acid and Caffeic Acid in Rats after Oral Administration

Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall

The antioxidant potential of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus , was investigated. The extract exhibited the most potent radical-scavenging activity at a maximum concentration of 10 mg/ml, and the scavenging effects were 56.20% and 60.02% on hydroxyl and superoxide radicals, respectively. The IC 50 values of the extract were found to be 8 mg/ml for hydroxyl and superoxide radicals. Ascorbic acid used as a standard was highly effective in inhibiting hydroxyl and superoxide radicals, showing IC 50 values of 6 mg/ml and 4 mg/ml respectively. At a maximum concentration of 10 mg/ml, the extract effected 56.12% inhibition of lipid peroxidation and 60.68% chelation of ferrous ions; also, at a maximum concentration 10 mg/ml, the extract manifested significant ( p P. ostreatus , has potent antioxidant activity. Industrial relevance The present study suggests that an ethanolic extract of the mushroom, Pleurotus ostreatus , could serve as an easily accessible item of food rich in natural antioxidants, as a possible food supplement or even as a pharmaceutical agent. Hence this study is considerable relevant to the food and pharmaceutical industries.

In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus

Six phenolic antioxidative compounds [5-caffeoylquinic acid (chlorogenic acid), 3,5-dicaffeoylquinic acid, quercetin 3-galactoside, quercetin 3-glucoside, quercetin 3-(6-malonylglucoside), and quercetin 3-(6-malonylgalactoside) (tentative)] were identified from the leaves of Corchorus olitorius L. (moroheiya) by NMR and FAB-MS. The contents of these phenolic compounds, ascorbic acid, and α-tocopherol in C. olitorius leaves were determined, and their antioxidative activities were measured using the radical generator-initiated peroxidation of linoleic acid. The results obtained showed that 5-caffeoylquinic acid was a predominant phenolic antioxidant in C. olitorius leaves. Keywords: Corchorus olitorius; antioxidants; phenolics; caffeoylquinic acid; quercetin glycosides

Katsunari Kohata

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Phenolic antioxidants from the leaves of Corchorus olitorius L.