K
Katsunori Ikari
Researcher at Keio University
Publications - 211
Citations - 6313
Katsunori Ikari is an academic researcher from Keio University. The author has contributed to research in topics: Rheumatoid arthritis & Medicine. The author has an hindex of 32, co-authored 178 publications receiving 5343 citations.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Yuta Kochi,Yukinori Okada,Akari Suzuki,Katsunori Ikari,Chikashi Terao,Atsushi Takahashi,Keiko Yamazaki,Naoya Hosono,Keiko Myouzen,Tatsuhiko Tsunoda,Naoyuki Kamatani,Tatsuya Furuichi,Shiro Ikegawa,Koichiro Ohmura,Tsuneyo Mimori,Fumihiko Matsuda,Takuji Iwamoto,Shigeki Momohara,Hisashi Yamanaka,Ryo Yamada,Michiaki Kubo,Yusuke Nakamura,Kazuhiko Yamamoto +22 more
TL;DR: The results suggest that CCR6 is critically involved in IL-17–driven autoimmunity in human diseases, and is associated with susceptibility to Graves' and Crohn's diseases.
Journal ArticleDOI
Association of STAT4 With Susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus in the Japanese Population
Shu Kobayashi,Katsunori Ikari,Hirotaka Kaneko,Yuta Kochi,Kazuhiko Yamamoto,Kenichi Shimane,Yusuke Nakamura,Yoshiaki Toyama,Takeshi Mochizuki,So Tsukahara,Yasushi Kawaguchi,Chihiro Terai,Masako Hara,Taisuke Tomatsu,Hisashi Yamanaka,Takahiko Horiuchi,Kayoko Tao,Koji Yasutomo,Daisuke Hamada,Natsuo Yasui,Hiroshi Inoue,Mitsuo Itakura,Hiroshi Okamoto,Naoyuki Kamatani,Shigeki Momohara +24 more
TL;DR: It is concluded that STAT4 is associated with rheumatoid arthritis and systemic lupus erythematosus in the Japanese, and is a common genetic risk factor for autoimmune diseases, with similar strength across major racial groups.
Journal ArticleDOI
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
Jing Cui,Eli A. Stahl,Eli A. Stahl,Eli A. Stahl,Saedis Saevarsdottir,Corinne Miceli,Corinne Miceli,Dorothee Diogo,Dorothee Diogo,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Maša Umiċeviċ Mirkov,Helena Canhão,Helena Canhão,Katsunori Ikari,Chikashi Terao,Yukinori Okada,Yukinori Okada,Sara Wedrén,Johan Askling,Hisashi Yamanaka,Shigeki Momohara,Atsuo Taniguchi,Koichiro Ohmura,Fumihiko Matsuda,Tsuneyo Mimori,Namrata Gupta,Manik Kuchroo,Manik Kuchroo,Ann W. Morgan,John D. Isaacs,Anthony G. Wilson,Kimme L. Hyrich,M M J Herenius,Marieke E. Doorenspleet,Paul P. Tak,Paul P. Tak,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Gertjan Wolbink,Gertjan Wolbink,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Nancy A. Shadick,Cornelia F Allaart,Tom W J Huizinga,René E. M. Toes,Robert P. Kimberly,S. Louis Bridges,Lindsey A. Criswell,Larry W. Moreland,João Eurico Fonseca,Niek de Vries,Barbara E. Stranger,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Soumya Raychaudhuri,Soumya Raychaudhuri,Michael E. Weinblatt,Peter K. Gregersen,Xavier Mariette,Xavier Mariette,Anne Barton,Leonid Padyukov,Marieke J H Coenen,Elizabeth W. Karlson,Robert M. Plenge,Robert M. Plenge +72 more
TL;DR: A genome-wide association study of more than 2 million common variants in rheumatoid arthritis patients shows that an allele associated with response to etanercept therapy is also associated with CD84 gene expression, and further that CD84 expression correlates with disease activity.