K
Katsuyuki Aozasa
Researcher at Osaka University
Publications - 433
Citations - 20429
Katsuyuki Aozasa is an academic researcher from Osaka University. The author has contributed to research in topics: Lymphoma & Cancer. The author has an hindex of 74, co-authored 433 publications receiving 19541 citations. Previous affiliations of Katsuyuki Aozasa include Nara Medical University.
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Journal ArticleDOI
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.
Rikinari Hanayama,Masato Tanaka,Kay Miyasaka,Katsuyuki Aozasa,Masato Koike,Yasuo Uchiyama,Shigekazu Nagata +6 more
TL;DR: It is reported that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8, a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptosis cells by macrophage.
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Pathogenic Significance of Interleukin-6 (IL-6/BSF-2) in Castleman's Disease
Kazuyuki Yoshizaki,Tadashi Matsuda,Norihiro Nishimoto,Taro Kuritani,L Taeho,Katsuyuki Aozasa,T Nakahata,H Kawai,Hiromi Tagoh,Toshihisa Komori +9 more
TL;DR: The findings in this report indicate that the generation of IL-6 by B cells in germinal centers of hyperplastic lymph nodes of Castleman's disease may be the key element responsible for the variety of clinical symptoms in this disease.
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Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease
Norihiro Nishimoto,Yuzuru Kanakura,Katsuyuki Aozasa,Takeshi Johkoh,Minoru Nakamura,Shuji Nakano,Nobuaki Nakano,Yasuo Ikeda,Takeshi Sasaki,Kiyoshi Nishioka,Masamichi Hara,Hirokuni Taguchi,Yukihiko Kimura,Yoshiro Kato,Hideki Asaoku,Shunichi Kumagai,F Kodama,H. Nakahara,Keisuke Hagihara,Kazuyuki Yoshizaki,Tadamitsu Kishimoto +20 more
TL;DR: Hemoglobin, albumin, and total cholesterol levels, high-density lipoprotein cholesterol values, and body mass index all increased significantly, and fatigue diminished, in patients with MCD.
Journal ArticleDOI
IgG1 plasmacytosis in interleukin 6 transgenic mice
Sachiko Suematsu,Tadashi Matsuda,Katsuyuki Aozasa,Shizuo Akira,Naoko Nakano,Shinsuke Ohno,Jun-ichi Miyazaki,Ken Ichi Yamamura,Toshio Hirano,Tadamitsu Kishimoto +9 more
TL;DR: The evidence indicates that deregulated gene expression of IL-6 can trigger polyclonal plasmacytosis but cannot induce plasmACYtoma, and it is suggested that additional genetic changes may be required for the generation of plasma cell neoplasia.
Journal ArticleDOI
Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
Yoshihiro Oka,Akihiro Tsuboi,Tetsuya Taguchi,Tadashi Osaki,Taiichi Kyo,Hiroko Nakajima,Olga A. Elisseeva,Yusuke Oji,Manabu Kawakami,Kazuhiro Ikegame,Naoki Hosen,Satoshi Yoshihara,Fei Wu,Fumihiro Fujiki,Masaki Murakami,Tomoki Masuda,Sumiyuki Nishida,Toshiaki Shirakata,Shin-ichi Nakatsuka,Ayako Sasaki,Keiko Udaka,Hiroo Dohy,Katsuyuki Aozasa,Shinzaburo Noguchi,Ichiro Kawase,Haruo Sugiyama +25 more
TL;DR: It was demonstrated that WT1 vaccination could induce WT1-specific cytotoxic T lymphocytes and result in cancer regression without damage to normal tissues.