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Kaushal Mahendra Shah

Bio: Kaushal Mahendra Shah is an academic researcher from Bharati Vidyapeeth University. The author has contributed to research in topics: Supernumerary & Posterior teeth. The author has an hindex of 4, co-authored 16 publications receiving 68 citations.

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Journal ArticleDOI
TL;DR: This review has been carried out to know about the component, functions of each component, mode of action, and beneficial effects of the garlic.
Abstract: Garlic is one of the components, which have effects on reducing the risk of cancer. Including garlic in the diet helps for the betterment of the health. Medicinal effects of the garlic were known since 5,000 years. Recently, studies were carried out to known its effect on the cancer cell lines. Many studies have shown its effects not only on carcinomas, but also on the cardiovascular system and immune system. Functions of the each component of the garlic were studied to know exactly, which component has got beneficial effect. So this review has been carried out to know about the component, functions of each component, mode of action, and beneficial effects of the garlic.

48 citations

Journal ArticleDOI
TL;DR: A middle aged patient came to the authors' dental out patients department with a complaint of burning sensation in right buccal mucosa and right side of tongue and an inability to eat spicy foods since a few months.
Abstract: A middle aged patient came to our dental out patients department with a complaint of burning sensation in right buccal mucosa and right side of tongue and an inability to eat spicy foods since a few months. Medical and family histories were non-contributory. The patient was not on any long-term medication either. However, the patient gave a dental history of fabrication of metal bridge for missing mandibular right molar a few years back. Intraoral examination revealed …

8 citations

Journal ArticleDOI
TL;DR: A rare case of dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth is reported, which was treated surgically by enucleation of the cyst.
Abstract: Most typical dentigerous cysts are commonly seen in association with third molars and maxillary canines. Only 5–6% of dentigerous cysts are associated with supernumerary teeth. We report a rare case of dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth. The patient was treated surgically by enucleation of the cyst.

7 citations

Journal ArticleDOI
TL;DR: A patient who came with tooth pain and extra-oral swelling which later on presented as multiple draining sinuses was reported, confirming cervicofacial actinomycosis, but presenting itself not as the typical ‘lumpy jaw’.
Abstract: Human actinomycosis is a rare soft tissue infection caused by Gram-positive, anaerobic bacteria Actinomyces israelii, a commensal of the oral cavity. The major clinical forms of actinomycosis are cervicofacial, thoracic, abdominal and pelvic forms. The cervicofacial region is most commonly affected. Actinomycosis is sometimes difficult to diagnose and it should be borne in mind in the differential diagnosis of numerous infectious and non-infectious diseases. We report a patient who came with tooth pain and extra-oral swelling which later on presented as multiple draining sinuses. Our initial suspicion was dento-alveolar abscess or osteomyelitis. However, a culture of the discharge and subsequent biopsy revealed actinomycetes, confirming cervicofacial actinomycosis, but presenting itself not as the typical ‘lumpy jaw’. The patient was successfully treated conservatively with a short but intensive antibiotic course.

7 citations

Journal ArticleDOI
TL;DR: A young boy presented to the department of oral medicine and radiology, with a chief complaint of pain and mobility of the lower posterior teeth and difficulty in mastication as mentioned in this paper. But then with the exfoliation, the inflammation subsided and gingiva appeared healthy.
Abstract: A young boy presented to the department of oral medicine and radiology, with a chief complaint of pain and mobility of the lower posterior teeth and difficulty in mastication. Clinical history as revealed by his mother was that he had normal development and eruption of deciduous teeth, but started losing teeth by the age of 3 years. She also noticed that his gingiva would become red, and swollen, and bleed easily, and emit foul smell. After exfoliation, the inflammation subsided and gingiva appeared healthy. But then with the …

3 citations


Cited by
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Journal ArticleDOI
K. Velsankar1, R M Aswin Kumar1, R. Preethi1, V Muthulakshmi1, S. Sudhahar1 
TL;DR: In this paper, the green synthesis of CuO nanoparticles was synthesized by Allium sativum extract and the powder X-ray diffraction pattern explained the high crystalline nature and the calculated crystallite size in 25−35'nm.
Abstract: The green synthesis of CuO nanoparticles was synthesized by Allium sativum extract. The powder X-ray diffraction pattern explained the high crystalline nature and the calculated crystallite size in 25−35 nm. The Fourier transform infrared spectrum described the CuO bonding nature. The UV visible analysis reported the surface Plasmon resonance band at 398 nm. The Photoluminescence spectrum denoted the red band emission in the visible region. The particle size analyzer displayed the CuO nanoparticles in a 20−40 nm range of size. The SEM images manifested the spherical, oval-shaped morphology of CuO nanoparticles. The EDAX spectrum and mapping proved the purity of CuO with Cu and O occurrence. The HRTEM images confirmed the crystalline nature formation of CuO nanoparticles. The phytochemical analysis listed the phytochemicals contributed for CuO nanoparticle synthesis via Allium sativum extract. The antimicrobial activity reported the efficient infection on bacteria as well as fungi. The antioxidant activity demonstrated the potential ability of free radical scavenging activity. The potential anti-inflammatory activity against egg albumin has obtained. The anti larvicidal activity showed the notable potential nature of affection on Anopheles subpictus mosquito larvae. At 21st century, CuO nanoparticles from environment friendly synthesis have special efficient applications in drugs, optics, batteries, gas sensors, catalysts, cosmetics, and semiconductor applications. Moreover, CuO nanoparticles have future applications in formulating the drug for human life-threatening diseases and various dangerous cancer treatments.

96 citations

Journal ArticleDOI
TL;DR: The present data suggest that allicin attenuated the LPS-induced vascular injury process, which may be closely related to the oxidative stress and inflammatory response in HUVECs.
Abstract: Background: Allicin, a major component of garlic, is regarded as a cardioprotective agent and is associated with increased endothelial function. Methods: The effects of allicin on lipopolysaccharide (LPS)-induced vascular oxidative stress and inflammation in cultured human umbilical vein endothelial cells (HUVECs) and the mechanisms underlying these effects were studied. The protective effects were measured using cell viability, a lactate dehydrogenase (LDH) assay and cell apoptosis as indicators, and the anti-oxidative activity was determined by measuring reactive oxygen species (ROS) generation, oxidative products and endogenous antioxidant enzyme activities. HUVEC mitochondrial function was assessed by determining mitochondrial membrane potential (MMP) collapse, cytochrome c production and mitochondrial ATP release. To investigate the potential underlying mechanisms, we also measured the expression of dynamic mitochondrial proteins using western blotting. Furthermore, we evaluated the Nrf2 antioxidant signaling pathway using an enzyme-linked immunosorbent assay (ELISA). Results: Our results demonstrated that allicin enhanced HUVEC proliferation, which was suppressed by LPS exposure, and LDH release. Allicin ameliorated LPS-induced apoptosis, suppressed ROS overproduction, reduced lipid peroxidation and decreased the endogenous antioxidant enzyme activities in HUVECs. These protective effects were associated with the inhibition of mitochondrial dysfunction as indicated by decreases in the MMP collapse, cytochrome c synthesis and mitochondrial ATP release. In addition, allicin attenuated the LPS-induced inflammatory responses, including endothelial cell adhesion and TNF-α and IL-8 production. Furthermore, allicin increased the expression of LXRα in a dose-dependent manner. Allicin-induced attenuation of inflammation was inhibited by LXRα siRNA treatment. Finally, allicin activated NF-E2-related factor 2 (Nrf2), which controls the defense against oxidative stress and inflammation. Conclusions: Taken together, the present data suggest that allicin attenuated the LPS-induced vascular injury process, which may be closely related to the oxidative stress and inflammatory response in HUVECs. Allicin modulated Nrf2 activation and protected the cells against LPS-induced vascular injury. Our findings suggest that allicin attenuated the LPS-induced inflammatory response in blood vessels.

94 citations

Journal ArticleDOI
TL;DR: Perioperative DATS treatment effectively ameliorates MI/R injury in type 1 diabetic setting by enhancing cardiac SIRT1 signaling, thus reducing myocardial apoptosis and eventually preserving cardiac function.
Abstract: Diallyl trisulfide (DATS) protects against apoptosis during myocardial ischemia-reperfusion (MI/R) injury in diabetic state, although the underlying mechanisms remain poorly defined. Previously, we and others demonstrated that silent information regulator 1 (SIRT1) activation inhibited oxidative stress and endoplasmic reticulum (ER) stress during MI/R injury. We hypothesize that DATS reduces diabetic MI/R injury by activating SIRT1 signaling. Streptozotocin (STZ)-induced type 1 diabetic rats were subjected to MI/R surgery with or without perioperative administration of DATS (40 mg/kg). We found that DATS treatment markedly improved left ventricular systolic pressure and the first derivative of left ventricular pressure, reduced myocardial infarct size as well as serum creatine kinase and lactate dehydrogenase activities. Furthermore, the myocardial apoptosis was also suppressed by DATS as evidenced by reduced apoptotic index and cleaved caspase-3 expression. However, these effects were abolished by EX527 (the inhibitor of SIRT1 signaling, 5 mg/kg). We further found that DATS effectively upregulated SIRT1 expression and its nuclear distribution. Additionally, PERK/eIF2α/ATF4/CHOP-mediated ER stress-induced apoptosis was suppressed by DATS treatment. Moreover, DATS significantly activated Nrf-2/HO-1 antioxidant signaling pathway, thus reducing Nox-2/4 expressions. However, the ameliorative effects of DATS on oxidative stress and ER stress-mediated myocardial apoptosis were inhibited by EX527 administration. Taken together, these data suggest that perioperative DATS treatment effectively ameliorates MI/R injury in type 1 diabetic setting by enhancing cardiac SIRT1 signaling. SIRT1 activation not only upregulated Nrf-2/HO-1-mediated antioxidant signaling pathway but also suppressed PERK/eIF2α/ATF4/CHOP-mediated ER stress level, thus reducing myocardial apoptosis and eventually preserving cardiac function.

76 citations

Journal ArticleDOI
TL;DR: The intent of this literature research is to explore the potential of garlic-derived products and bioactive organosulfur compounds as cancer chemopreventive and chemotherapeutic agents and concerns and limitations that have arisen in past studies regarding standards of measurement, bioavailability, and method of delivery are addressed.

62 citations

Journal ArticleDOI
TL;DR: Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease.
Abstract: The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

58 citations