Author
Kazuhiko Ichino
Bio: Kazuhiko Ichino is an academic researcher from Meijo University. The author has contributed to research in topics: Actinodaphne & Dihydrochalcone. The author has an hindex of 13, co-authored 31 publications receiving 516 citations.
Topics: Actinodaphne, Dihydrochalcone, Flavanone, Total synthesis, Flavonolignan
Papers
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TL;DR: Two new biphenyl ether lignans were isolated from the leaves of Magnolia obovata THUNB and showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans, but was less active than magnolol (5) and honokiol (6).
Abstract: Two new biphenyl ether lignans, named obovatol (1) and obovatal (2) were isolated from the leaves of Magnolia obovata THUNB. (Magnoliaceae) and their chemical structures were determined to be 4', 5-diallyl-2, 3-dihydroxybiphenyl ether and 3, 4-dihydroxy-5-(pallylphenoxy) cinnamic aldehyde by means of chemical and spectral studies. The former substance showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans, but was less active than magnolol (5) and honokiol (6).
81 citations
TL;DR: In this article, six new lactones, litsenolide D 1, L 2, L 3, L 4, L 5, L 6, L 7, L 8, L 9, L 10, hamabiwalactone A, and hamabibibibilactone B, were isolated from Litsea japonica and elucidated on the basis of spectroscopic evidence.
48 citations
TL;DR: In this article, a new phenolic amide, N-trans-feruloyl 3-methyldopamine, along with N-Trans-ferulooyl tyramine, was found in Actinodaphne longifolia.
41 citations
TL;DR: New neolignans, denudatin A and B (hydrobenzofuranoids) and denudatone [spiro(5,5)undecanoid], together with three known NELLANS including burchelli are described in this paper.
33 citations
TL;DR: In this article, a chalcone, linderachalcone and a dihydrochalcone, methyllinderatin, were isolated from the leaves of Lindera umbellata var. membranacea.
28 citations
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TL;DR: The integrated inventory of these compounds and their biological macromolecular end-points highlights the opportunities that phytocannabinoids offer to access desirable drug-like space beyond the one associated to the narcotic target CB1.
507 citations
TL;DR: The aim of this study was to review a variety of experimental and clinical reports and, describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of Magnolia and/or its constituents.
370 citations
320 citations
TL;DR: Oxidative stress is a cardinal hallmark of the disease and has been considered as therapeutic target for AD treatment, and antioxidant neuroprotective effects and therapeutic potential for AD of selected natural polyphenolic compounds are described.
281 citations
TL;DR: In this paper, complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans, silybins A (1) and B (2), and isosily bins A(3) and C(4) from the seeds of milk thistle (Silybum marianum) were achieved for the first time using a preparative reversed-phase HPLC method.
Abstract: Complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans, silybins A (1) and B (2), and isosilybins A (3) and B (4) from the seeds of milk thistle (Silybum marianum) were achieved for the first time using a preparative reversed-phase HPLC method. In addition, three other flavonolignans, silychristin (5) isosilychristin (6) and silydianin (7), and a flavonoid, taxifolin (8) were isolated. Structures, including absolute stereochemistries of 1-4, were confirmed using 2D NMR and CD spectroscopy.
267 citations