K
Kazuhiko Yamamoto
Researcher at University of Tokyo
Publications - 844
Citations - 33533
Kazuhiko Yamamoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Immune system & Rheumatoid arthritis. The author has an hindex of 82, co-authored 778 publications receiving 29369 citations. Previous affiliations of Kazuhiko Yamamoto include St. Marianna University School of Medicine & Japanese Ministry of Health, Labour and Welfare.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
Akari Suzuki,Ryo Yamada,Xiaotian Chang,Shinya Tokuhiro,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Makiko Nakayama-Hamada,Reimi Kawaida,Mitsuru Ono,Masahiko Ohtsuki,Hidehiko Furukawa,Shinichi Yoshino,Masao Yukioka,Shigeto Tohma,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Yuichi Nishioka,Akihiro Sekine,Aritoshi Iida,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +24 more
TL;DR: The results imply that the PADI4 haplotype associated with susceptibility to rheumatoid arthritis increases production of citrullinated peptides acting as autoantigens, resulting in heightened risk of developing the disease.
Journal ArticleDOI
Treatment of rheumatoid arthritis with humanized anti–interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
Norihiro Nishimoto,Kazuyuki Yoshizaki,Nobuyuki Miyasaka,Kazuhiko Yamamoto,Shinichi Kawai,Tsutomu Takeuchi,Jun Hashimoto,Junichi Azuma,Tadamitsu Kishimoto +8 more
TL;DR: Treatment with MRA was generally well tolerated and significantly reduced the disease activity of RA, and the adverse events were not dose dependent.
Journal ArticleDOI
Cytokine-mediated regulation of CXCR4 expression in human neutrophils.
Hiroyuki Nagase,Misato Miyamasu,Masao Yamaguchi,Masako Imanishi,Nelson H. Tsuno,Kouji Matsushima,Kazuhiko Yamamoto,Yutaka Morita,Koichi Hirai +8 more
TL;DR: Results on PMNs support the argument that the SDF‐1 (CXCL12)/CXCR4 system is regulated by cell type‐specific mechanisms.
Journal ArticleDOI
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
Norihiro Nishimoto,Jun Hashimoto,Nobuyuki Miyasaka,Kazuhiko Yamamoto,Shinichi Kawai,Tsutomu Takeuchi,Norikazu Murata,Désirée van der Heijde,Tadamitsu Kishimoto +8 more
TL;DR: Tocilizumab monotherapy was generally well tolerated and provided radiographic benefit in patients with RA and improved signs and symptoms.