K
Kazuhiro Aoki
Researcher at National Institutes of Natural Sciences, Japan
Publications - 297
Citations - 10859
Kazuhiro Aoki is an academic researcher from National Institutes of Natural Sciences, Japan. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 51, co-authored 256 publications receiving 9458 citations. Previous affiliations of Kazuhiro Aoki include Tokyo Medical and Dental University & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
The afterglow of GRB 050709 and the nature of the short-hard γ-ray bursts
D. B. Fox,D. B. Fox,Dale A. Frail,P. A. Price,Shrinivas R. Kulkarni,Edo Berger,Tsvi Piran,Tsvi Piran,Alicia M. Soderberg,Stephen Bradley Cenko,P. B. Cameron,Avishay Gal-Yam,Mansi M. Kasliwal,D.-S. Moon,Fiona A. Harrison,Ehud Nakar,Brian P. Schmidt,Bryan E. Penprase,Roger A. Chevalier,Pawan Kumar,Kathy Roth,Darach Watson,Brian L. Lee,Stephen A. Shectman,Mark M. Phillips,Miguel Roth,Patrick J. McCarthy,Michael Rauch,L. L. Cowie,Bruce A. Peterson,Joshua Rich,Nobuyuki Kawai,Kazuhiro Aoki,G. Kosugi,Tomonori Totani,H-S Park,Andrew MacFadyen,Kevin Hurley +37 more
TL;DR: In this article, the X-ray afterglow of a short-hard burst, GRB 050709, was found to be associated with a star-forming galaxy at redshift z = 0.160.
Journal ArticleDOI
Development of an optimized backbone of FRET biosensors for kinases and GTPases
Naoki Komatsu,Kazuhiro Aoki,Masashi Yamada,Hiroko Yukinaga,Yoshihisa Fujita,Yuji Kamioka,Michiyuki Matsuda +6 more
TL;DR: An optimized backbone for the rapid development of a highly sensitive intramolecular fluorescence resonance energy transfer (FRET) biosensor is reported, which includes an optimized pair of fluorescent proteins and a long flexible linker ranging from 116 to 244 amino acids in length.
Journal ArticleDOI
Selective inhibition of NF-|[kappa]|B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Eijiro Jimi,Eijiro Jimi,Kazuhiro Aoki,Hiroaki Saito,Fulvio D'Acquisto,Michael J. May,Michael J. May,Ichiro Nakamura,Testuo Sudo,Takefumi Kojima,Fujio Okamoto,Hidefumi Fukushima,Koji Okabe,Keiichi Ohya,Sankar Ghosh +14 more
TL;DR: Selective inhibition of NF-κB activation offers an effective therapeutic approach for inhibiting chronic inflammatory diseases involving bone resorption, and significantly reduced the severity of collagen-induced arthritis in mice.
Journal ArticleDOI
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
Aki Fujioka,Kenta Terai,Reina E. Itoh,Kazuhiro Aoki,Takeshi Nakamura,Shinya Kuroda,Eisuke Nishida,Michiyuki Matsuda +7 more
TL;DR: A kinetic simulation model consisting of the minimum essential members of the Ras/ERK MAPK cascade reproduced essential features of the observed activation and nuclear translocation of ERK.
Journal ArticleDOI
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.
G Sabatakos,Natalie A. Sims,Jingshan Chen,Kazuhiro Aoki,Max B. Kelz,Michael Amling,Yasmina Bouali,K Mukhopadhyay,K Ford,Eric J. Nestler,Roland Baron +10 more
TL;DR: Because osteoblasts and adipocytes are thought to share a common precursor, it is concluded that ΔFosB transcriptionally regulates osteoblastogenesis, possibly at the expense of adipogenesis.