Author
Kazuhiro Higuchi
Bio: Kazuhiro Higuchi is an academic researcher from Meiji Pharmaceutical University. The author has contributed to research in topics: Indole test & Total synthesis. The author has an hindex of 15, co-authored 44 publications receiving 1031 citations.
Topics: Indole test, Total synthesis, Aryne, Nucleophile, Chemistry
Papers
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TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
531 citations
TL;DR: The first total synthesis of (+/-)-hinckdentine A is accomplished, followed by acid-mediated Mannich-type C-C bond formation of 2-hydroxyindolin-3-one, seven-membered ring closure, and regioselective tribromination.
90 citations
TL;DR: The first total synthesis of (-)-fructigenine A and a novel approach to (-)-5-N-acetylardeemin through a common imine intermediate (+)-3 are described.
Abstract: The first total synthesis of (−)-fructigenine A and a novel approach to (−)-5-N-acetylardeemin through a common imine intermediate (+)-3 are described. The key steps include highly enantioselective preparation of (+)-3 via domino olefination/isomerization/Claisen rearrangement (OIC) of 5, reductive cyclization (RC), and regioselective oxidation of (−)-4 and a novel assembly of the pyrazino ring of these alkaloids via Ugi three-component reaction/cyclization of (+)-3 with the corresponding amino acid and isonitrile.
47 citations
TL;DR: The cyclization of tryptamine with DMSO and Tf(2)O, followed by substitution with indole derivatives, produced racemic 3a-indolylpyrroloindolines.
44 citations
TL;DR: The asymmetric total synthesis of (-)-leuconoxine has been achieved and the desymmetrization of a prochiral diester using a chiral phosphoric acid catalyst produced a highly enantioenriched lactam with excellent yield.
42 citations
Cited by
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TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
TL;DR: Stereoselective Addition to N-Activated Pyridines James A. Bull, Guillaume Pelletier,† and Andre ́ B. Charette are credited for this work.
Abstract: Stereoselective Addition to N-Activated Pyridines James A. Bull,‡ James J. Mousseau, Guillaume Pelletier,† and Andre ́ B. Charette*,† †Department of Chemistry, Universite ́ de Montreál, P.O. Box 6128, Station Downtown, Montreál, Queb́ec, Canada H3C 3J7 ‡Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, U.K. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
679 citations
663 citations
645 citations
TL;DR: This review focused on the recent development of indole derivatives as antiviral agents and summarized the structure property, hoping to inspire new and even more creative approaches to discover novel drugs with different modes of action.
575 citations