K
Kazumi Sugihara
Researcher at International University, Cambodia
Publications - 88
Citations - 3494
Kazumi Sugihara is an academic researcher from International University, Cambodia. The author has contributed to research in topics: Aldehyde oxidase & Microsome. The author has an hindex of 29, co-authored 87 publications receiving 3115 citations. Previous affiliations of Kazumi Sugihara include Hiroshima University.
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Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.
Shigeyuki Kitamura,Tomoharu Suzuki,Seigo Sanoh,Ryuki Kohta,Norimasa Jinno,Kazumi Sugihara,Shin'ichi Yoshihara,Nariaki Fujimoto,Hiromitsu Watanabe,Shigeru Ohta +9 more
TL;DR: The results suggest that the 4-hydroxyl group of the A- phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities.
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Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.
Tomoharu Suzuki,Shigeyuki Kitamura,Ryuki Khota,Kazumi Sugihara,Nariaki Fujimoto,Shigeru Ohta +5 more
TL;DR: Results suggest that a 4-hydroxyl group on the phenyl ring of benzophenone derivatives is essential for high hormonal activities, and the presence of other hydroxyl groups markedly alters these activities.
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Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells.
Hiroyuki Kojima,Shinji Takeuchi,Naoto Uramaru,Kazumi Sugihara,Takahiko Yoshida,Shigeyuki Kitamura +5 more
TL;DR: The results suggest that PBDEs and their metabolites might have multiple endocrine-disrupting effects via nuclear hormone receptors, and para-HO-PBDEs, in particular, possess more potent receptor activities compared with those of the parent PB DEs and corresponding para-MeO-PB DEs.
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Drug-Metabolizing Ability of Molybdenum Hydroxylases
TL;DR: Drug-drug interactions associated with aldehyde oxidase and xanthine oxidoreductase are of potential clinical significance and the variation of the activity is described in this review.
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Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture.
Shigeyuki Kitamura,Norimasa Jinno,Tomoharu Suzuki,Kazumi Sugihara,Shigeru Ohta,Hiroaki Kuroki,Nariaki Fujimoto +6 more
TL;DR: It is suggested that, at least for the 17 PCB congeners and hydroxylated metabolites tested, a 4-hydroxyl group in PCBs is essential for thyroid hormonal and estrogenic activities, and that 3,5-dichloro substitution favors thyroid hormonal activity, but not estrogenic activity.