K
Kazuo Shinozuka
Researcher at Gunma University
Publications - 109
Citations - 2653
Kazuo Shinozuka is an academic researcher from Gunma University. The author has contributed to research in topics: Moiety & Phosphoramidite. The author has an hindex of 18, co-authored 109 publications receiving 2571 citations. Previous affiliations of Kazuo Shinozuka include Kyushu University.
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Inhibitors for replication of retroviruses and for the expression of oncogene products
TL;DR: In this paper, the authors proposed a method to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
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Physicochemical properties of phosphorothioate oligodeoxynucleotides.
TL;DR: The syntheses, melting temperatures, and nuclease susceptibilities of a series of phosphorothioate ODN analogs are reported, providing a rational basis for the S-dC/G sequences as potential effective anti-AIDS agents.
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Phosphorothioate and normal oligodeoxyribonucleotides with 5'-linked acridine: characterization and preliminary kinetics of cellular uptake.
TL;DR: Reports of melting temperatures (Tm) of a series of S-oligos compared with those of the corresponding normal oligomers and the uptake of these fluorescently labeled oligos into HL60 cells suggest an energy-dependent process, and a possible membrane receptor for oligos.
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Involvement of the glutamate receptor δ2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells
TL;DR: An antisense oligonucleotide against the glutamate receptor delta 2 subunit mRNA, which is selectively expressed only in Purkinje neurons, suppressed the induction of long-term depression (LTD) of glutamate responsiveness in the rat cerebellar culture.
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Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.
Stéphane Daviet,Sophie Couvé-Privat,Laurent Gros,Kazuo Shinozuka,Hiroshi Ide,Murat Saparbaev,Alexander A. Ishchenko +6 more
TL;DR: The data suggest that NIR is a backup system for the BER pathway to remove oxidative damage to cytosines in vivo and biochemical coupling of the nucleotide incision and exonuclease degradation may serve to remove clustered DNA damage.