Author
Kazuo Watanabe
Bio: Kazuo Watanabe is an academic researcher from Kobe Gakuin University. The author has contributed to research in topics: Magnolia salicifolia. The author has an hindex of 1, co-authored 1 publications receiving 29 citations.
Topics: Magnolia salicifolia
Papers
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TL;DR: The structures of magnosalin and magnoshinin, new neolignans isolated from buds of Magnolia salicifolia MAXIM, were determined to be 1 and 4, respectively, on the basis of chemical and spectroscopic evidence as discussed by the authors.
Abstract: The structures of magnosalin and magnoshinin, new neolignans isolated from buds of Magnolia salicifolia MAXIM., were determined to be 1 and 4, respectively, on the basis of chemical and spectroscopic evidence.
33 citations
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TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
Abstract: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis.1 Since then, significant progress has been achieved in this discipline; many powerful single bond forming reactions and asymmetric variants have been developed. These discoveries have paved the way for the stereoselective assembly of complex organic molecules, a task deemed inconceivable by early practitioners. A great many strategies were invented by chemists in order to facilitate the synthesis of complex natural products.2 One avenue in emulating nature’s efficiency would * To whom correspondence should be addressed. E-mail: dennis.hall@ ualberta.ca. † Novartis Institute for Biomedical Research. ‡ Department of Chemistry, University of Alberta. Chem. Rev. 2009, 109, 4439–4486 4439
1,374 citations
TL;DR: This method has been adapted to the synthesis of the natural products magnosalin and pellucidin A and key to minimizing competing cycloreversion is the inclusion of an aromatic electron relay (ER).
Abstract: A direct method to synthesize lignan cyclobutanes and analogs via photoinduced electron transfer is presented. A variety of oxygenated alkenes are employed to furnish terminal or substituted cyclobutane adducts with complete regiocontrol, yielding cycloadducts with trans stereochemistry. Key to minimizing competing cycloreversion is the inclusion of an aromatic electron relay (ER). This method has been adapted to the synthesis of the natural products magnosalin and pellucidin A.
127 citations
TL;DR: Anti-inflammatory activities of these compounds were determined by measuring nitric oxide levels in the medium using murine microglia BV-2 cells on the basis of the expanded understanding that inflammation is a crucial cause of tumor progression.
34 citations
TL;DR: Magnoshinin (1) was conveniently synthesized from Easarone (2) under photochemical conditions as mentioned in this paper, and the conversion of cyclobutane type dimers was also described
32 citations
TL;DR: In this paper, seven additional compounds have been isolated from Piper cubeba and characterized as heterotropan, magnosalin, 2,4,5-trimethoxybenzaldehyde, α- and β- O -ethyl cubebins, 5″-methoxyhinokinin and the monoacetate of dihydrocubebin.
32 citations