Kazuo Yanada

Bio: Kazuo Yanada is an academic researcher from Kobe Gakuin University. The author has contributed to research in topics: Magnolia salicifolia & Rubredoxin. The author has an hindex of 3, co-authored 4 publications receiving 50 citations.

Isolation and structure of magnosalin and magnoshinin, new neolignans from magnolia saliciforia maxim

Abstract: The structures of magnosalin and magnoshinin, new neolignans isolated from buds of Magnolia salicifolia MAXIM., were determined to be 1 and 4, respectively, on the basis of chemical and spectroscopic evidence.

Neuromuscular Blocking Action of Alkaloids from a Japanese Crude Drug “Shin-I” (Flos Magnoliae) in Frog Skeletal Muscle

Abstract: From the dried buds of MAGNOLIA SALICIFOLIA M AXIM, D-coclaurine ( 1), D-reticuline ( 2), 1-N-methylcoclaurine ( 3) and yuzirine ( 4) were isolated. Fifty percent inhibitory doses (μM) in acetylcholine (ACh, 27.5 μM)-induced contraction of frog skeletal muscle were as follows: D-tubocuraine ( D-TC) 3.09, 2 93.2, 3 211, 1 467 and 4 more than 945. 4 (94.5 and 315 μM) increased the ACh-induced contraction. Indirectly stimulated twitching of frog nerve-muscle preparations were completely blocked by the following doses (μM): D-TC 1.47, 1 31.1, 2 239 and 3 more than 257. 1, 2 and 3 did not or only slightly block directly stimulated twitching. In contrast 271 μM 4 blocked the directly stimulated twitching.

Oxidized rubredoxin model. novel synthesis by ligand-substitution with disulfide

Abstract: [Fe (SPh)4]1 (lox) and [Fe (S-p-tol)4]1 (2ox), new oxidized rubredoxin model compounds, were synthesized in solution by the ligand-substitution of [Fe (S2-o-xyl)2]1 (3ox) with 10 eq diaryl disulfide in the presence of 2 eq o-xylene-α, α'-dithiol and were characterized by visible and ESR spectra. This method is useful to prepare unstable Fe (III) tetrathiolate complexes containing simple monodentate ligands.

Natural product synthesis using multicomponent reaction strategies.

Abstract: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis.1 Since then, significant progress has been achieved in this discipline; many powerful single bond forming reactions and asymmetric variants have been developed. These discoveries have paved the way for the stereoselective assembly of complex organic molecules, a task deemed inconceivable by early practitioners. A great many strategies were invented by chemists in order to facilitate the synthesis of complex natural products.2 One avenue in emulating nature’s efficiency would * To whom correspondence should be addressed. E-mail: dennis.hall@ ualberta.ca. † Novartis Institute for Biomedical Research. ‡ Department of Chemistry, University of Alberta. Chem. Rev. 2009, 109, 4439–4486 4439

Synthesis of cyclobutane lignans via an organic single electron oxidant–electron relay system

Abstract: A direct method to synthesize lignan cyclobutanes and analogs via photoinduced electron transfer is presented. A variety of oxygenated alkenes are employed to furnish terminal or substituted cyclobutane adducts with complete regiocontrol, yielding cycloadducts with trans stereochemistry. Key to minimizing competing cycloreversion is the inclusion of an aromatic electron relay (ER). This method has been adapted to the synthesis of the natural products magnosalin and pellucidin A.

Alkaloids of the Annonaceae: occurrence and a compilation of their biological activities.

Abstract: This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided. The alkaloids of the aporphine type represent the predominant group in this family. Many of the isolated alkaloids exhibit unique structures. In addition to the chemical structures, the pharmacological activities of some alkaloids are also presented in this chapter. Thus, the leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids are highlighted. The chapter is presented as a contribution for the scientific community, mainly to enable the search for alkaloids in species belonging to the Annonaceae family.