K
Kazushige Mori
Researcher at Hoffmann-La Roche
Publications - 4
Citations - 1488
Kazushige Mori is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Thymidine phosphorylase & Cachexia. The author has an hindex of 4, co-authored 4 publications receiving 1440 citations.
Papers
More filters
Journal ArticleDOI
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
Masanori Miwa,Masako Ura,Miwa Nishida,Noriaki Sawada,Tohru Ishikawa,Kazushige Mori,Nobuo Shimma,I. Umeda,Hideo Ishitsuka +8 more
TL;DR: Capecitabine, which is finally converted to 5-FU by dThdPase in tumours, should be much safer and more effective than5-FU, and this was indeed the case in the HCT116 human colon cancer and the MX-1 breast cancer xenograft models.
Journal ArticleDOI
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues.
TL;DR: An ELISA method sensitive enough to measure dThdPase levels, even in tumor tissue samples weighing as little as 10 mg, is developed, which is essential for the activation of 5'-dFUrd.
Journal ArticleDOI
Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma.
TL;DR: The finding of the presence of IL‐6 in the serum of mice bearing clone 5, which does not induce weight loss, clearly indicates that IL‐5 is not solely responsible for the induction of cachexia, and points to the involvement of IL-6 in experimental cachexia.
Journal ArticleDOI
Murine interleukin‐12 prevents the development of cancer cachexia in a murine model
Kazushige Mori,Kaori Fujimoto-Ouchi,Tohru Ishikawa,Fumiko Sekiguchi,Hideo Ishitsuka,Yutaka Tanaka +5 more
TL;DR: The results indicate that the anticachectic activity of IL‐12 is T‐cell‐dependent and results from at least 2 mechanisms, the down‐regulation ofIL‐6 and the up-regulation of IFN‐γ.