scispace - formally typeset
Search or ask a question
Author

Keerti Jain

Bio: Keerti Jain is an academic researcher from Delhi Institute of Pharmaceutical Sciences and Research. The author has contributed to research in topics: Drug delivery & Dendrimer. The author has an hindex of 25, co-authored 51 publications receiving 3096 citations. Previous affiliations of Keerti Jain include Central University, India & Maharaja Sayajirao University of Baroda.


Papers
More filters
Journal ArticleDOI
TL;DR: The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrisers inThe field of drug delivery.

861 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the approaches available to overcome the cationic toxicity inherent associated with the dendrimers is presented, where two strategies have been utilized; first, designing and synthesis of biocompatible dendrrimers; and second, masking of peripheral charge of dendrigers by surface engineering.

624 citations

Journal ArticleDOI
TL;DR: This review presents an overview of different applications of glycosylated carriers, with a focus on their applicability in development of a nanoconstruct with GRAS status.

229 citations

Journal ArticleDOI
TL;DR: Properties of mucoadhesion, the state in which two materials adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules.
Abstract: Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems.

205 citations

Journal ArticleDOI
TL;DR: The core shell Alg-CS-NPs showed promising potential for oral delivery and significantly enhanced the in vivo oral absorption of enoxaparin.

192 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
Abstract: Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc) in the treatment of various diseases The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (eg, natural products) and selective diagnosis through disease marker molecules The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed In addition, we have included information regarding the trends and perspectives in nanomedicine area

3,112 citations

Journal ArticleDOI
TL;DR: The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrisers inThe field of drug delivery.

861 citations

Journal ArticleDOI
TL;DR: Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review.
Abstract: The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

771 citations

Journal ArticleDOI
TL;DR: Current challenges to the development of synthetic RNAi-based therapies are explored and new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release are considered.
Abstract: Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.

736 citations

Journal ArticleDOI
TL;DR: In this paper, the authors highlight the recent development of smart drug delivery systems for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles and carbon nanotubes.

576 citations