Author
Keiichi Hayashizaki
Bio: Keiichi Hayashizaki is an academic researcher from Kyoto University. The author has contributed to research in topics: Enantioselective synthesis & Aldol reaction. The author has an hindex of 5, co-authored 9 publications receiving 580 citations.
Papers
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258 citations
TL;DR: Aldol reaction of methyl α-isocyanocarboxylates (CNCH(R)COOMe: R = H, Me, Et, i -Pr) with benzaldehyde or acetaldehyde in the presence of 0.5-1.0 mol% of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) complex gave optically active 4-methoxycarbonyl-4,5-dialkyl-2-oxazolines with high enantioselectivity in a quantitative
148 citations
TL;DR: Aldol reaction of methyl α-isocyanocarboxylates (CNCH(R)COOMe: R = H, Me, Et, i-Pr, Ph) with paraformaldehyde in the presence of 1 mol% of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) complex gave optically active 4-alkyl-2-oxazoline-4-carboxylate as mentioned in this paper.
106 citations
TL;DR: In this article, cross-coupling of 2-methyl-1-naphthylmagnesium bromide with 1,5-and 1,4-dibromonaphthalenes in the presence of a chiral ferrocenylphosphine-nickel catalyst (PPFOMe/Ni) gave axially chiral ternaphthaleners, (R, R )-2,2″-dimethyl-1,1′:5′,1″-ternaphthalene (98.7% ee
71 citations
TL;DR: In this article, the authors present a solution for poly(ethyleneimine[N-vinylbenzoyl]) with ouverture de cycle and poly(polymerization radicalaire et anionique en solution) corresponding to le polymere vinylique correspondant.
Abstract: La polymerisation radicalaire et anionique en solution donne le polymere vinylique correspondant. La polymerisation cationique avec ouverture de cycle donne la poly(ethyleneimine[N-vinylbenzoyl])
10 citations
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1,378 citations
TL;DR: The results show clear trends in gold-Catalyzed C-H Bond Functionalization and Selective Reductions, and catalytic Hydrogenation of Alkenes and 1,3-Dienes, as well as in other areas of science.
Abstract: 2.7. Hydroxylation Reactions of Allenes 3282 2.8. Hydroamination Reactions of Allenes 3284 2.9. Hydrothiolation of Allenes 3284 2.10. Hydroalxoxylation of Alkenes and 1,3-Dienes 3286 2.11. Hydroamination of Alkenes and 1,3-Dienes 3287 2.12. Hydrothiolation of Conjugated Olefins 3289 3. Activation of Carbonyl/Imine Groups and Alcohols 3289 3.1. Condensation Reactions 3289 3.2. Addition Reactions 3291 3.3. Aldol Reactions 3294 3.4. Hydroand Carbosilylation Reactions 3295 3.5. Nucleophilic Substitution Reactions of Alcohols 3297 4. Gold-Catalyzed C-H Bond Functionalization 3297 4.1. Csp3-H Bond Functionalization 3298 4.2. Csp2-H Bond Functionalization 3299 4.3. Csp-H Bond Functionalization 3304 5. Gold-Catalyzed Selective Reductions 3305 5.1. Catalytic Hydrogenation of Alkenes 3306 5.2. Selective Reductions of R, -Unsaturated Carbonyl Groups and 1,3-Dienes 3306
1,358 citations
TL;DR: Nickel-Catalyzed Cross-Couplings Involving Carbon-Oxygen Bonds Brad M. Rosen, Kyle W. Quasdorf, Daniella A. Wilson, Na Zhang, Ana-Maria Resmerita, Neil K. Garg, and Virgil Percec report on cross-coupling strategies for high-performance liquid chromatography of carbon dioxide and nitrogen.
Abstract: Nickel-Catalyzed Cross-Couplings Involving Carbon-Oxygen Bonds Brad M. Rosen, Kyle W. Quasdorf, Daniella A. Wilson, Na Zhang, Ana-Maria Resmerita, Neil K. Garg,* and Virgil Percec* Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States
1,100 citations
TL;DR: This Review classifies strategies in the asymmetric synthesis of axially chiral biaryl compounds according to their underlying concepts and critically evaluates their scope and limitations with reference to selected model reactions and applications.
Abstract: A rotationally hindered and thus stereogenic biaryl axis is the structurally and stereochemically decisive element of a steadily growing number of natural products, chiral auxiliaries, and catalysts. Thus, it is not surprising that significant advances have been made in the asymmetric synthesis of axially chiral biaryl compounds over the past decade. In addition to the classic approach (direct stereoselective aryl-aryl coupling), innovative concepts have been developed in which the asymmetric information is introduced into a preformed, but achiral-that is, symmetric or configurationally labile-biaryl compound, or in which an aryl--C single bond is stereoselectively transformed into an axis. This Review classifies these strategies according to their underlying concepts and critically evaluates their scope and limitations with reference to selected model reactions and applications. Furthermore, the preconditions required for the existence of axial chirality in biaryl compounds are discussed.
985 citations
976 citations