K
Keiichi Hiramatsu
Researcher at Juntendo University
Publications - 342
Citations - 33010
Keiichi Hiramatsu is an academic researcher from Juntendo University. The author has contributed to research in topics: Staphylococcus aureus & SCCmec. The author has an hindex of 79, co-authored 339 publications receiving 31180 citations. Previous affiliations of Keiichi Hiramatsu include Samsung Medical Center & Hiroshima University.
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Journal ArticleDOI
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.
TL;DR: Therapy was resumed with the com -bination of arbekacin and ampicillin/sulbactam which has been shown to have synergic activity against MRSA.
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Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Makoto Kuroda,Toshiko Ohta,Ikuo Uchiyama,Tadashi Baba,Harumi Yuzawa,Ichizo Kobayashi,Longzhu Cui,Akio Oguchi,Ken-ichi Aoki,Yoshimi Nagai,JianQi Lian,Teruyo Ito,Mutsumi Kanamori,Hiroyuki Matsumaru,Atsushi Maruyama,Hiroyuki Murakami,Akira Hosoyama,Yoko Mizutani-Ui,Noriko K. Takahashi,Toshihiko Sawano,Ryu-ichi Inoue,Chikara Kaito,Kazuhisa Sekimizu,Hideki Hirakawa,Satoru Kuhara,Susumu Goto,Junko Yabuzaki,Minoru Kanehisa,Atsushi Yamashita,Kenshiro Oshima,Keiko Furuya,Chie Yoshino,Tadayoshi Shiba,Masahira Hattori,Naotake Ogasawara,Hideo Hayashi,Keiichi Hiramatsu +36 more
TL;DR: Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve the understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus.
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Genome and virulence determinants of high virulence community-acquired MRSA.
Tadashi Baba,Fumihiko Takeuchi,Makoto Kuroda,Harumi Yuzawa,Ken-ichi Aoki,Akio Oguchi,Yoshimi Nagai,Natsuko Iwama,Kazuyuki Asano,Timothy S. Naimi,Hiroko Kuroda,Longzhu Cui,Kenji Yamamoto,Keiichi Hiramatsu +13 more
TL;DR: The whole genome sequence of MW2, a strain of community-acquired MRSA, was ascertained by shotgun cloning and sequencing and found that it carried a range of virulence and resistance genes that was distinct from those displayed on the chromosomes of extant S aureus strains.
Journal ArticleDOI
Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
Keiichi Hiramatsu,Nanae Aritaka,Hideaki Hanaki,Shiori Kawasaki,Yasuyuki Hosoda,Satoshi Hori,Yoshinosuke Fukuchi,Intetsu Kobayashi +7 more
TL;DR: Heterogeneously resistant VRSA was found in hospitals throughout Japan, which could explain, at least partly, the frequent therapeutic failure of MRSA infection with vancomycin in Japan.
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A New Class of Genetic Element, Staphylococcus Cassette Chromosome mec, Encodes Methicillin Resistance in Staphylococcus aureus
TL;DR: It is proposed that SCCmec driven by a novel set of recombinases represents a new family of staphylococcal genomic elements.