J. Appl. Cryst.の発刊に際して

Improving drug solubility for oral delivery using solid dispersions.

https://onlinelibrary.wiley.com/doi/pdf/10.1021/js980403l

Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs

Cyclodextrins as pharmaceutical solubilizers.

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.

Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate

Chitosan films, varying in molecular weight and degree of deacetylation, were prepared by a casting technique using acetic acid as a dissolving vehicle. The physicochemical properties of the films were characterized. Both molecular weight and degree of deaceylation affected the film properties. Powder X-ray diffraction patterns and differential scanning calorimetry thermograms of all chitosan films indicated their amorphous state to partially crystalline state with thermal degradation temperature lower than 280-300 degrees C. The increase in molecular weight of chitosan would increase the tensile strength and elongation as well as moisture absorption of the films, whereas the increase in degree of deacetylation of chitosan would either increase or decrease the tensile strength of the films depending on its molecular weight. Moreover, the higher the degree of deacetylation of chitosan the more brittle and the less moisture absorption the films became. All chitosan films were soluble in HCl-KCl buffer (pH 1.2), normal saline, and distilled water. They swelled in phosphate buffer (pH 7.4), and cross-linking between chitosan and phosphate anions might occur Finally, transmission infrared and 13C-NMR spectra supported that chitosan films prepared by using acetic acid as a dissolving were chitosonium acetate films.

Physical Properties and Molecular Behavior of Chitosan Films

Drug physical state and drug-polymer interaction on drug release from chitosan matrix films.

Inhibitory effects of water-soluble polymers on precipitation of RS-8359

Purpose
The stabilization mechanism of a supersaturated solution of mefenamic acid (MFA) from a solid dispersion with EUDRAGIT® EPO (EPO) was investigated.

/pdf/stabilization-of-a-supersaturated-solution-of-mefenamic-acid-1ex5qs2gib.pdf

Keiji Yamamoto

Papers

Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate

Physical Properties and Molecular Behavior of Chitosan Films

Drug physical state and drug-polymer interaction on drug release from chitosan matrix films.

Inhibitory effects of water-soluble polymers on precipitation of RS-8359

Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT(®) EPO