K
Keir C. Neuman
Researcher at National Institutes of Health
Publications - 117
Citations - 7007
Keir C. Neuman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA supercoil & Topoisomerase. The author has an hindex of 34, co-authored 101 publications receiving 6159 citations. Previous affiliations of Keir C. Neuman include École Normale Supérieure & Princeton University.
Papers
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Journal ArticleDOI
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Keir C. Neuman,Attila Nagy +1 more
TL;DR: These techniques are described and illustrated with examples highlighting current capabilities and limitations of single-molecule force spectroscopy.
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Characterization of photodamage to Escherichia coli in optical traps.
TL;DR: A wavelength-tunable optical trap was employed in which the microscope objective transmission was fully characterized throughout the near infrared, in conjunction with a sensitive, rotating bacterial cell assay, and the intensity dependence for photodamage was linear, supporting a single-photon process.
Journal ArticleDOI
Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking.
TL;DR: It is proposed that ubiquitous pauses in transcription do not result from the backtracking of RNAP along the DNA template, but are caused by a structural rearrangement within the enzyme.
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Sequence-Resolved Detection of Pausing by Single RNA Polymerase Molecules
Kristina M. Herbert,Arthur La Porta,Becky J. Wong,Rachel A. Mooney,Keir C. Neuman,Robert Landick,Steven M. Block +6 more
TL;DR: Data obtained for the lifetimes and efficiencies of pauses support a model where the transition to pausing branches off of the normal elongation pathway and is mediated by a common elemental state, which corresponds to the ubiquitous pause.
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High-order harmonic generation in atom clusters.
TL;DR: Clusters containing about 10 atoms are produced in a high-pressure gas jet and are shown to be a unique nonlinear medium that yields higher appearance intensity for a given harmonic order, stronger nonlinear dependence of harmonic signal on laser intensity, higher-order harmonics, and reduced saturation of the harmonic signal at high laser intensity.