Keishi Makino

TL;DR: It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities.

TL;DR: It is reported that HER-2/neu activates Akt (protein kinase B) to promote prostate cancer cell survival and growth in the absence of androgen.

TL;DR: It is demonstrated that DOC-2/hDab-2 expression in breast cancer cells resulted in sensitivity to suspension-induced cell death (anoikis), and this event was associated with the down-regulation of the integrin-linked kinase (ILK) activity.

TL;DR: The results demonstrate that upregulation of IKKα and IKKβ by the ILK/Akt pathway is required for the HER2/neu-mediated NF-κB antiapoptotic pathway.

TL;DR: Comparison of the activity of inhibitor of nuclear factor-κB (IκB) kinase (IKK) and the degradation of IκBα in E1A transfectants and parental human cancer cells after ionizing radiation treatment suggests that inhibition of IKK activity and IKKB degradation is the predominant mechanism for E 1A-mediated inhibition of radiation-induced NF-κBs activity.