Kelly Del Tredici

TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.

TL;DR: To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis.

TL;DR: Parkinsons disease is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system as discussed by the authors, where the intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites advances in a topographically predictable sequence.

TL;DR: Evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of A&bgr; plaques and neurofibrillary tangles.

TL;DR: The data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region.