Keman Liao

TL;DR: The data demonstrate that circFOXO3 can exert regulatory functions in GBM and that ceRNA-mediated microRNA sequestration might be a potential strategy for GBM therapy.

TL;DR: The MALAT1/miR-199a/ZHX1 axis promotes GBM cell proliferation and progression in vitro and in vivo, and its expression negatively correlates with GBM patient survival, which can serve as a novel therapeutic strategy for treating GBM.

TL;DR: The present study is the first to establish thatAHIF promotes glioblastoma progression and radioresistance via exosomes, which suggests that AHIF is a potential therapeutic target for GBM.

TL;DR: It is demonstrated that asparaginyl endopeptidase binds to and directly cleaves WT-p53, resulting in the inhibition of WT- p53-mediated tumor suppressor function in both tumor cells and stromal cells via extracellular vesicle communication.

TL;DR: It is found that a novel LGMN pseudogene (LGM NP1) was upregulated in glioblastoma (GBM) tissues and high LGMNP1 expression in GBM cells enhanced proliferation and invasion and CeRNA-mediated miRNA sequestration might be a novel therapeutic strategy in G BM.