Author
Keming Wang
Bio: Keming Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Small molecule & Streptavidin. The author has an hindex of 4, co-authored 4 publications receiving 102 citations.
Papers
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TL;DR: A colorimetric method that could be observed with naked eye and used copper nanoclusters for cost-effective detection of DNA in Hepatitis B virus, which has potential applications in correct diagnosis of genetic disease and monitoring of gene therapy in the poverty-stricken areas.
65 citations
TL;DR: Results show that sensitive and specific detection of both streptavidin and biotin can be achieved, and this method can be extended for the detection of other small molecule-protein couples, and thereby has the potential for biomedical and clinical applications.
29 citations
TL;DR: The results indicated that the HRCA method had a favorable specificity in analyzing proteins or small molecules and may be expected to quantitatively analyze some protein markers and small molecular drugs in complex biological samples.
25 citations
TL;DR: A novel and effective electrochemical method that can detect human DNMT1 activity effectively and has successfully been applied in complex biological samples, it may have great potential in the applications in DNA methylation related clinical practices and biochemical researches.
12 citations
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TL;DR: In this overview, studies concerning nanotechnology-based biosensors for pathogenic virus detection have been summarized, paying special attention to graphene oxide, silica, carbon nanotubes, gold, silver, zinc oxide and magnetic nanoparticles, which could pave the way to detect viral diseases and provide healthy life for infected patients.
Abstract: Viruses are real menace to human safety that cause devastating viral disease. The high prevalence of these diseases is due to improper detecting tools. Therefore, there is a remarkable demand to identify viruses in a fast, selective and accurate way. Several biosensors have been designed and commercialized for detection of pathogenic viruses. However, they present many challenges. Nanotechnology overcomes these challenges and performs direct detection of molecular targets in real time. In this overview, studies concerning nanotechnology-based biosensors for pathogenic virus detection have been summarized, paying special attention to biosensors based on graphene oxide, silica, carbon nanotubes, gold, silver, zinc oxide and magnetic nanoparticles, which could pave the way to detect viral diseases and provide healthy life for infected patients.
207 citations
TL;DR: A review of various nucleic acid-based biosensors, the different read-out strategies employed, and their use in chemical and biological sensing and how rational design of such constructs leads to more efficient biosensing platforms.
Abstract: Development of biosensing platforms plays a key role in research settings for identification of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids have taken many forms, from simple duplex-based constructs to stimuli-responsive nucleic acid nanostructures. In this review, we look at various nucleic acid-based biosensors, the different read-out strategies employed, and their use in chemical and biological sensing. We also look at current developments in DNA nanotechnology-based biosensors and how rational design of such constructs leads to more efficient biosensing platforms.
180 citations
TL;DR: Theoretical and experimental studies have shown that copper NCs (CuNCs) possess unique photoluminescent properties, and it is pointed out that in-situ generation of CuNCs for sensing and bioimaging may be an entry point for the in-depth studies of Cu NCs as an intriguing probe.
101 citations
TL;DR: The presented approach holds great promise to develop on-demand hybrid system for a variety of applications ranging from biosensor and biomedicine to biocatalytic process.
85 citations
TL;DR: This review comprehensively tracks the preparation of DNA-CuNPs and its application in biosensing, and highlights the potential development and challenges regarding this field, aiming to promote the advance of this fertile research area.
76 citations