K
Ken-ichi Harada
Researcher at Meijo University
Publications - 278
Citations - 12531
Ken-ichi Harada is an academic researcher from Meijo University. The author has contributed to research in topics: Mass spectrometry & High-performance liquid chromatography. The author has an hindex of 61, co-authored 260 publications receiving 11974 citations. Previous affiliations of Ken-ichi Harada include University of Helsinki.
Papers
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Journal ArticleDOI
Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity.
Shigeru Yoshizawa,Rie Matsushima,Mariyo F. Watanabe,Ken-ichi Harada,Akira Ichihara,Wayne W. Carmichael,Hirota Fujiki +6 more
TL;DR: The hepatotoxicity of microcystins and nodularin may result from inhibition of protein phosphatases and the increase of phosphoproteins, which is similar to that of okadaic acid in the nanomolar range of concentration.
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A Nonempirical Method Using LC/MS for Determination of the Absolute Configuration of Constituent Amino Acids in a Peptide: Combination of Marfey's Method with Mass Spectrometry and Its Practical Application
TL;DR: In this article, an advanced version of the Marfey's method was proposed to determine the absolute configuration of constituent amino acids in a peptide using liquid chromatography/mass spectrometry (LC/MS).
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Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green-algae)
Wayne W. Carmichael,Val R. Beasley,David L. Bunner,Jacobus Nicolaas Eloff,Ian R. Falconer,Paul R. Gorham,Ken-ichi Harada,Thaiya Krishnamurthy,Yu Min-Juan,Richard E. Moore,Kenneth L. Rinehart,Maria T. C. Runnegar,Olav M. Skulberg,Mariyo F. Watanabe +13 more
TL;DR: All photographs courtesy of AFP, EPA, Getty Images and Reuters.
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Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans.
Kiyoshi Terao,S. Ohmori,Kazuei Igarashi,Ikuko I. Ohtani,Mariyo F. Watanabe,Ken-ichi Harada,Emiko Ito,Masayuki Watanabe +7 more
TL;DR: It was clearly demonstrated that cylindrospermopsin is a potent inhibitor of the protein synthesis and the amount of total P450 was extensively diminished in the toxin treated with hepatic microsomes.
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Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method
Ken-ichi Harada,Ikuko I. Ohtani,Kayoko Iwamoto,Makoto Suzuki,Mariyo F. Watanabe,Masayuki Watanabe,Kiyoshi Terao +6 more
TL;DR: A rapid screening method including four steps, extraction, clean-up, separation, and determination, has been proposed for cylindrospermopsin, which causes fatty liver and central necroses in mice and is suspected of being an agent causing human hepatoenteritis.