Author
Kenan Buldurun
Other affiliations: İnönü University
Bio: Kenan Buldurun is an academic researcher from Muş Alparslan University. The author has contributed to research in topics: Schiff base & Ligand. The author has an hindex of 9, co-authored 32 publications receiving 195 citations. Previous affiliations of Kenan Buldurun include İnönü University.
Topics: Schiff base, Ligand, Chemistry, Transfer hydrogenation, Ruthenium
Papers
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TL;DR: In this article, two Schiff base ligands (L1 and L2) derived from condensation of methyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate, both starting matter with 5-bromo-salicylaldehyde, have been prepared using a molar ratio of ligand:metal as 1:1 except the Ru(II) complexes 1:0.5.
49 citations
TL;DR: In this article, two different Schiff base Fe(II) and Co-II metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde.
Abstract: Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with Ki values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.
44 citations
TL;DR: In this paper, a new Schiff base ligand and its two M(II) complexes [CoCl·L(H2O)2]·2H 2O, [RuCl(p-cymene)L] were synthesized and the structural features were confirmed from their micro analytical, IR, UV-Vis., 1H 13C NMR, TGA, X-ray diffraction analysis, mass spectral data and magnetic susceptibility measurements.
37 citations
TL;DR: To determine the antioxidant properties of Schiff base ligand and its Ni(II), Ru(II) metal complexes, FRAP, CUPRAC, ABTS and DPPH methods of antioxidant assays were used.
Abstract: The new complex compounds [RuLCl(p-cymene)] ⋅ 3H2 O and [NiL2 (H2 O)2 ] ⋅ 3H2 O (L: 1-{4-[(2-hydroxy-3-methoxybenzylidene)amino]phenyl}ethanone) were prepared and characterized using FT-IR, 1 H- and 13 C-NMR, mass spectroscopy, TGA, elemental analysis, X-ray powder diffraction and magnetic moment techniques. Octahedral geometry for new Ni(II) and Ru(II) complexes was proposed. Thermal decomposition confirmed the existence of lattice and coordinated water molecule in the complexes. To determine the antioxidant properties of Schiff base ligand and its Ni(II), Ru(II) metal complexes, FRAP, CUPRAC, ABTS and DPPH methods of antioxidant assays were used. Moreover, enzyme inhibition of complexes was evaluated against carbonic anhydrase I and II isoenzymes (CA I and CA II) and acetylcholinesterase (AChE). For CA I and CA II, the best inhibition enzymes, was the Ni(II) complex with 62.98±18.41, 86.17±23.62 Ki values, whereas this inhibition effect showed ligand with 24.53±2.66 Ki value for the AChE enzyme.
27 citations
TL;DR: The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II] and palladium(II) complexes were successfully prepared and the structure was elucidated by various techniques.
Abstract: The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II) and palladium(II) complexes were successfully prepar...
24 citations
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TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
Abstract: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes. Screening of antioxidant properties of plants and plant-derived compounds requires appropriate methods, which address the mechanism of antioxidant activity and focus on the kinetics of the reactions including the antioxidants. Many studies evaluating the antioxidant activity of various samples of research interest using different methods in food and human health have been conducted. These methods are classified, described, and discussed in this review. Methods based on inhibited autoxidation are the most suited for termination-enhancing antioxidants and for chain-breaking antioxidants, while different specific studies are needed for preventive antioxidants. For this purpose, the most common methods used in vitro determination of antioxidant capacity of food constituents were examined. Also, a selection of chemical testing methods was critically reviewed and highlighted. In addition, their advantages, disadvantages, limitations and usefulness were discussed and investigated for pure molecules and raw extracts. The effect and influence of the reaction medium on the performance of antioxidants are also addressed. Hence, this overview provides a basis and rationale for developing standardized antioxidant methods for the food, nutraceuticals, and dietary supplement industries. In addition, the most important advantages and shortcomings of each method were detected and highlighted. The chemical principles of these methods are outlined and critically discussed. The chemical principles of methods of 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonate) radical (ABTS·+) scavenging, 1,1-diphenyl-2-picrylhydrazyl (DPPH·) radical scavenging, Fe3+-Fe2+ transformation assay, ferric reducing antioxidant power (FRAP) assay, cupric ions (Cu2+) reducing power assay (Cuprac), Folin-Ciocalteu reducing capacity (FCR assay), peroxyl radical (ROO·), superoxide radical anion (O2·-), hydrogen peroxide (H2O2) scavenging assay, hydroxyl radical (OH·) scavenging assay, singlet oxygen (1O2) quenching assay, nitric oxide radical (NO·) scavenging assay and chemiluminescence assay are outlined and critically discussed. Also, the general antioxidant aspects of main food components were discussed by a number of methods, which are currently used for the detection of antioxidant properties of food components. This review consists of two main sections. The first section is devoted to the main components in the food and pharmaceutical applications. The second general section comprises some definitions of the main antioxidant methods commonly used for the determination of the antioxidant activity of components. In addition, some chemical, mechanistic and kinetic basis, and technical details of the used methods are given.
677 citations
01 Jan 2006
TL;DR: The evidence for metal-based neurodegeneration in Parkinson's and Alzheimer's disease was presented in this article, where metal ion homeostatic control, particularly of redox-active metals such as iron and copper, in specific brain regions, leads to the generation of reactive oxygen species, which either directly damage key proteins, or lead to the formation of reactive aldehydes.
Abstract: The hypothesis is presented that changes in metal ion homeostatic control, particularly of redox-active metals such as iron and copper, in specific brain regions, leads to the generation of reactive oxygen species, which either directly damage key proteins, or lead to the formation of reactive aldehydes. These, in turn, generate protein carbonyls, leading to protein denaturation, aggregation, and a failure of the ubiquitin/proteasome system to eliminate these defective proteins. We present the evidence for metal based neurodegeneration in Parkinson's and Alzheimer's disease. Possible therapeutic strategies are presented which could remove such excesses of these specific metals and lead to the diminishment of the neurodegenerative processes. (C) 2007 Elsevier B.V. All rights reserved.
210 citations
TL;DR: In this article, the synthesis of Co(II), Cu(II) and Zn(II)-complexes of bidentate Schiff base ligand (L) 2-((1H-Benzo [d]imidazole-4ylimmino) methyl phenol is presented.
71 citations
TL;DR: In this article, the synthesis of compounds of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds were evaluated against the human erythrocyte carbonic anhydrase I, and II isoenzymes, butyrylcholinesterase (BChE), and α-glycosidase enzymes.
56 citations
TL;DR: Through flow cytometry, it is demonstrated that all compounds were efficient in inducing apoptosis effect in K562 and MG63 cell lines except Schiff base- chitosan inK562 cell lines.
55 citations