K
Kenji Fukasawa
Researcher at University of Cincinnati Academic Health Center
Publications - 60
Citations - 8624
Kenji Fukasawa is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Centrosome & Centrosome duplication. The author has an hindex of 42, co-authored 60 publications receiving 8376 citations. Previous affiliations of Kenji Fukasawa include University of Cincinnati.
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Journal ArticleDOI
Transformation of mammalian cells by constitutively active MAP kinase kinase
Sam J. Mansour,W. T. Matten,April S. Hermann,Julian M. Candia,Sing Rong,Kenji Fukasawa,G F Vande Woude,Natalie G. Ahn +7 more
TL;DR: It is found that constitutive activation of MAPKK is sufficient to promote cell transformation and is associated with highly tumorigenic in nude mice.
Journal ArticleDOI
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
Nicholas S. Duesbery,Craig P. Webb,Stephen H. Leppla,Valery M. Gordon,Kurt Klimpel,Terry D. Copeland,Natalie G. Ahn,M Oskarsson,Kenji Fukasawa,Ken D. Paull,George F. Vande Woude +10 more
TL;DR: It is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway.
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Abnormal Centrosome Amplification in the Absence of p53
TL;DR: In mouse embryonic fibroblasts lacking the p53 tumor suppressor protein, multiple copies of functionally competent centrosomes are generated during a single cell cycle, implicate p53 in the regulation of centrosome duplication and suggest one possible mechanism by which the loss of p53 may cause genetic instability.
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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Masaru Okuda,Henning F. Horn,Pheruza Tarapore,Yukari Tokuyama,A. George Smulian,Pui K. Chan,Erik S. Knudsen,Irene A. Hofmann,Jean D. Snyder,Kevin E. Bove,Kenji Fukasawa +10 more
TL;DR: NPM/B23 is identified as a substrate of CDK2/cyclin E in centrosome duplication and is a target ofCDK 2/cycl in the initiation of centrosomes duplication in vivo.
Journal ArticleDOI
Centrosome amplification, chromosome instability and cancer development.
TL;DR: How centrosome amplification destabilizes chromosomes, how loss of certain tumor suppressor proteins leads to centrosomes amplification, and the role of centrosom amplification in cancer development will be discussed.