Author
Kenji Hara
Bio: Kenji Hara is an academic researcher from Fukuoka University. The author has contributed to research in topics: Solid-phase microextraction & Poison control. The author has an hindex of 19, co-authored 115 publications receiving 1292 citations.
Papers published on a yearly basis
Papers
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TL;DR: Regression equations for methamphetamine and amphetamine showed excellent linearity in the range of 0.25-200 ng/0.5 ml, and intra- and inter-day coefficients of variations for both stimulants were not greater than 10.8%.
92 citations
TL;DR: An accurate, simple and rapid method for qualitative and quantitative analysis of amphetamine and methamphetamine in urine was developed using head space-solid phase microextraction and gas chromatography-mass spectrometry/chemical ionization selected iron monitoring.
88 citations
TL;DR: A simple and sensitive method for the simultaneous analysis of fenfluramine, amphetamine and methamphetamine in whole blood was developed using a headspace-solid phase microextraction (SPME) and derivatization and was applied to a suicide case in which the victim ingested fenFLuramine.
56 citations
TL;DR: A simple method for hair analysis of methamphetamine (MAMP) and amphetamine (AMP) by gas chromatography-mass spectrometry (GC-MS) was developed using simultaneous headspace solid-phase microextraction (HS-SPME) with derivatization.
54 citations
TL;DR: The feasibility of detecting methamphetamine and its major metabolite, amphetamine, in postmortem tissues over a 2-year period was examined as discussed by the authors, and the results showed that despite long term storage, drug abuse and/or toxicity could be determined, in all tissues examined.
48 citations
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TL;DR: Experimental NeurologyBy Prof. Paul Glees.
Abstract: Experimental Neurology By Prof Paul Glees Pp xii + 532 (Oxford: Clarendon Press; London: Oxford University Press, 1961) 75s net
1,559 citations
TL;DR: Improved chromatographic-mass spectrometric techniques with increased selectivity and sensitivity and new methods of sample preparation have substantially enhanced the ability to detect numerous drugs and other poisons in hair.
908 citations
TL;DR: Repeated use of methamphetamine may induce neurotoxicity, associated with prolonged psychiatric symptoms, cognitive impairment and an increased risk of developing Parkinson's disease.
Abstract: Aims To examine the literature regarding clinical pharmacokinetics, direct effects and adverse clinical outcomes associated with methamphetamine use.
Methods Relevant literature was identified through a PubMed search. Additional literature was obtained from relevant books and monographs.
Findings and conclusions The mean elimination half-life for methamphetamine is approximately 10 hours, with considerable inter-individual variability in pharmacokinetics. Direct effects at low-to-moderate methamphetamine doses (5–30 mg) include arousal, positive mood, cardiac stimulation and acute improvement in cognitive domains such as attention and psychomotor coordination. At higher doses used typically by illicit users (≥50 mg), methamphetamine can produce psychosis. Its hypertensive effect can produce a number of acute and chronic cardiovascular complications. Repeated use may induce neurotoxicity, associated with prolonged psychiatric symptoms, cognitive impairment and an increased risk of developing Parkinson's disease. Abrupt cessation of repeated methamphetamine use leads to a withdrawal syndrome consisting of depressed mood, anxiety and sleep disturbance. Acute withdrawal lasts typically for 7–10 days, and residual symptoms associated with neurotoxicity may persist for several months.
597 citations
TL;DR: The current methods being used to identify body fluid stains including blood, semen, saliva, vaginal fluid, urine, and sweat are analyzed, and the potential of new biospectroscopic techniques based on Raman and fluorescence spectroscopy is evaluated for rapid, confirmatory, non-destructive identification of a body fluid at a crime scene.
570 citations
TL;DR: UHPLC has recently become a wide-spread analytical technique in many laboratories which focus on fast and sensitive bio-analytical assays and the key advantages are the increased speed of analysis, higher separation efficiency and resolution, higher sensitivity and much lower solvent consumption as compared to other analytical approaches.
519 citations