Kenji Ikeda

TL;DR: The common occurrence of intracellular accumulations of TDP-43 supports the hypothesis that these disorders represent a clinicopathological entity of a single disease, and suggests that they can be newly classified as a proteinopathy of T DP-43.

TL;DR: The phenotype of T cells in the AD brain indicates that they are activated but are not fully differentiated, and local inflammatory conditions might cause accumulation and activation of T cell in theAD brain.

TL;DR: In vivo and in vitro studies showed the effective uptake of A beta by microglia, and evidence also indicates that these cells eliminate A beta from the brain.

TL;DR: Investigation of isoform composition of aggregated tau protein in brains with Pick's disease, corticobasal degeneration and progressive supranuclear palsy by immunoblot analysis of sarkosyl-insoluble fractions of brain homogenates suggests tau isoforms involved in the pathological processes differ between CBD/PSP and PiD, and are thus disease specific.

TL;DR: Thrombin was detected immunohistochemically in brain tissue of Alzheimer's disease patients and age-matched controls, suggesting that thrombin formation from prothrombin probably takes place in AD brain.