K
Kenji Nakamura
Researcher at Mitsubishi
Publications - 26
Citations - 5569
Kenji Nakamura is an academic researcher from Mitsubishi. The author has contributed to research in topics: Vascular endothelial growth factor A & Knockout mouse. The author has an hindex of 18, co-authored 26 publications receiving 5102 citations. Previous affiliations of Kenji Nakamura include Tokai University.
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Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
Deletion of Peg10 , an imprinted gene acquired from a retrotransposon, causes early embryonic lethality
Ryuichi Ono,Kenji Nakamura,Kimiko Inoue,Mie Naruse,Takako Usami,Noriko Wakisaka-Saito,Toshiaki Hino,Rika Suzuki-Migishima,Narumi Ogonuki,Hiromi Miki,Takashi Kohda,Atsuo Ogura,Minesuke Yokoyama,Minesuke Yokoyama,Tomoko Kaneko-Ishino,Fumitoshi Ishino +15 more
TL;DR: The production of mice that lack Peg10 indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development.
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Role of retrotransposon-derived imprinted gene, Rtl1 , in the feto-maternal interface of mouse placenta
Yoichi Sekita,Hirotaka Wagatsuma,Kenji Nakamura,Ryuichi Ono,Masayo Kagami,Noriko Wakisaka,Noriko Wakisaka,Toshiaki Hino,Rika Suzuki-Migishima,Takashi Kohda,Atsuo Ogura,Tsutomu Ogata,Minesuke Yokoyama,Minesuke Yokoyama,Tomoko Kaneko-Ishino,Fumitoshi Ishino +15 more
TL;DR: It is demonstrated that retrotransposon-derived Rtl1 (retrotranspos on-like 1), also known as Peg11 (paternally expressed 11), is essential for maintenance of the fetal capillaries, and that both its loss and its overproduction cause late-fetal and/or neonatal lethality in mice.
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Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.
Ikuo Yana,Hiroshi Sagara,Satoshi Takaki,Kiyoshi Takatsu,Kenji Nakamura,Kazuki Nakao,Motoya Katsuki,Shun'ichiro Taniguchi,Takanori Aoki,Hiroshi Sato,Stephen J. Weiss,Motoharu Seiki +11 more
TL;DR: It is demonstrated that vascular maturation coordinated by endothelial cell/mural cell interactions redirects MT1-MMP expression to the neovessel tip where the protease regulates matrix remodeling at the leading edge of the developing vasculature.
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Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant
Satoru Muto,Atsu Aiba,Y. Saito,Kazuki Nakao,Kenji Nakamura,Kyoichi Tomita,Tadaichi Kitamura,Masahiko Kurabayashi,Ryozo Nagai,Eiji Higashihara,Peter C. Harris,Motoya Katsuki,Shigeo Horie,Shigeo Horie +13 more
TL;DR: Data indicated that molecular defects observed in Pkd1(-/-) embryos contributed to the pathogenesis of ADPKD and that thiazolidinediones had a compensatory effect on the pathway affected by the loss of polycystin-1.