Kenji Takagi

TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.

TL;DR: In this article, the authors reveal the molecular mechanism of p62/Sqstm1-dependent malignant progression, and suggest that molecular targeting of P62/sqstmm1 represents a potential chemotherapeutic approach against hepatocellular carcinoma (HCC).

TL;DR: Results demonstrate that the mode of DLGex binding to Keap1 is distinct from that of ETGE structurally, thermodynamically, and kinetically and support the contention that theDLGex motif serves as a converter transmitting environmental stress to Nrf2 induction as the latch site.

TL;DR: The data show that FYCO1 requires a functional LIR motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected.

TL;DR: It is shown that ALFY binds selectively to LC3C and the GABARAPs through a LIR in its WD40 domain, indicating that residues outside the LIR‐binding hydrophobic pockets confer specificity to the interactions with Atg8 homolog proteins.