K
Kenneth A. Bradley
Researcher at University of California, Los Angeles
Publications - 58
Citations - 4606
Kenneth A. Bradley is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Anthrax toxin & Bacillus anthracis. The author has an hindex of 30, co-authored 58 publications receiving 4357 citations. Previous affiliations of Kenneth A. Bradley include University of Wisconsin-Madison & Harvard University.
Papers
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Journal ArticleDOI
Identification of the cellular receptor for anthrax toxin.
Kenneth A. Bradley,Jeremy Mogridge,Jeremy Mogridge,Michael Mourez,Robert J. Collier,John A. Young +5 more
TL;DR: The cloning of the human PA receptor is described using a genetic complementation approach and a soluble version of this domain can protect cells from the action of the toxin.
Journal ArticleDOI
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
TL;DR: A soluble version of the CMG2 VWA/I domain inhibited intoxication of cells expressing endogenous toxin receptors when it was added to PA at a 3:1 ratio and identified a potent antitoxin that may prove useful for the treatment of anthrax.
Journal ArticleDOI
Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping
Saji George,Suman Pokhrel,Tian Xia,Benjamin Gilbert,Zhaoxia Ji,Marco Schowalter,Andreas Rosenauer,Robert Damoiseaux,Kenneth A. Bradley,Lutz Mädler,Andre E. Nel +10 more
TL;DR: The utility of a rapid throughput, integrated biological oxidative stress response pathway to perform hazard ranking of a small batch of metal oxide nanoparticles is demonstrated, in addition to showing how this assay can be used to improve nanosafety by decreasing ZnO dissolution through Fe doping.
Journal ArticleDOI
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.
Saji George,Tian Xia,Robert Rallo,Robert Rallo,Yan Zhao,Zhaoxia Ji,Sijie Lin,Xiang Wang,Haiyuan Zhang,David Schoenfeld,Robert Damoiseaux,Rong Liu,Shuo Lin,Kenneth A. Bradley,Yoram Cohen,Andre E. Nel +15 more
TL;DR: A multiparametric, automated screening assay that incorporates sublethal and lethal cellular injury responses to perform high-throughput analysis of a batch of commercial metal/metal oxide nanoparticles (NP) with the inclusion of a quantum dot (QD1) is reported.