K
Kenneth P. Olive
Researcher at Columbia University
Publications - 111
Citations - 11048
Kenneth P. Olive is an academic researcher from Columbia University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 29, co-authored 86 publications receiving 8794 citations. Previous affiliations of Kenneth P. Olive include Cancer Research UK & Massachusetts Institute of Technology.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Andrew D. Rhim,Andrew D. Rhim,Paul E. Oberstein,Dafydd H. Thomas,Emily T. Mirek,Carmine F. Palermo,Stephen A. Sastra,Erin N. Dekleva,Tyler Saunders,Claudia P. Becerra,Ian W. Tattersall,C. Benedikt Westphalen,Jan Kitajewski,Maite G. Fernandez-Barrena,Martin E. Fernandez-Zapico,Christine A. Iacobuzio-Donahue,Kenneth P. Olive,Ben Z. Stanger +17 more
TL;DR: De deleting Shh in a well-defined mouse model of PDAC demonstrated that some components of the tumor stroma can act to restrain tumor growth, and administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors.
Journal ArticleDOI
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.
Kenneth P. Olive,David A. Tuveson,Zachary C. Ruhe,Bob Yin,Nicholas A. Willis,Roderick T. Bronson,Denise Crowley,Tyler Jacks,Tyler Jacks +8 more
TL;DR: It is demonstrated that point mutant p53 alleles expressed under physiological control have enhanced oncogenic potential beyond the simple loss of p53 function.
Journal ArticleDOI
Stromal biology and therapy in pancreatic cancer
Albrecht Neesse,Patrick Michl,Kristopher K. Frese,Christine Feig,Natalie Cook,Mike A Jacobetz,Martijn P. Lolkema,Malte Buchholz,Kenneth P. Olive,Thomas M. Gress,David A. Tuveson +10 more
TL;DR: Stromal cells contained within the PDA tumour microenvironment represent an additional constituent to neoplastic cells that should be critically evaluated for optimal therapeutic development in preclinical models and early clinical trials.
Journal ArticleDOI
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A. Badgley,Daniel M. Kremer,H. Carlo Maurer,H. Carlo Maurer,Kathleen E. DelGiorno,Ho-Joon Lee,Vinee Purohit,Irina Sagalovskiy,Alice Ma,Jonathan Kapilian,Christina E. M. Firl,Amanda R. Decker,Steve A. Sastra,Carmine F. Palermo,Leonardo R. Andrade,Peter Sajjakulnukit,Li Zhang,Zachary P. Tolstyka,Tal Hirschhorn,Candice Lamb,Tong Liu,Wei Gu,E. Scott Seeley,Everett Stone,George Georgiou,Uri Manor,Alina Iuga,Geoffrey M. Wahl,Brent R. Stockwell,Costas A. Lyssiotis,Kenneth P. Olive +30 more
TL;DR: This work shows that the import of oxidized cysteine (cystine) via system xC– is a critical dependency of pancreatic ductal adenocarcinoma (PDAC), which is a leading cause of cancer mortality.