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Kenneth S. Polonsky

Researcher at University of Chicago

Publications -  280
Citations -  34484

Kenneth S. Polonsky is an academic researcher from University of Chicago. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 99, co-authored 278 publications receiving 33209 citations. Previous affiliations of Kenneth S. Polonsky include Asahikawa Medical College & Howard Hughes Medical Institute.

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Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

TL;DR: Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usually before the age of 25 years and frequently in childhood or adolescence, and a primary defect in the function of the beta cells of the pancreas.
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Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

TL;DR: It is shown that the volume of distribution and kinetic parameters of C-peptide distribution and metabolism vary by <30% in a population highly heterogenous in terms of age, sex, degree of obesity, and degree of glucose tolerance.
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Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

TL;DR: In obesity, although hypersecretion of insulin can be documented, the temporal pattern of secretion is largely unaltered, which suggests that the functioning beta cell mass is enhance, but normal regulatory mechanisms influencing secretion are still operative.