K
Kenyon G. Daniel
Researcher at Wayne State University
Publications - 24
Citations - 1829
Kenyon G. Daniel is an academic researcher from Wayne State University. The author has contributed to research in topics: Proteasome & Proteasome inhibitor. The author has an hindex of 17, co-authored 24 publications receiving 1589 citations. Previous affiliations of Kenyon G. Daniel include University of South Florida.
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The Significance of Chirality in Drug Design and Development
TL;DR: From exploration of structure space to governmental regulations it is clear that the question of chirality in drug design is of vital importance and only key chiral structures, enantiomers based on relative stereochemistry need be included, and lead to a compromise between exploration of chemical space and maintaining manageable libraries.
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Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
TL;DR: The feature of breast cancer cells and tissues to accumulate copper can be used as a targeting method for anticancer therapy through treatment with novel compounds such as CQ and PDTC that become active proteasome inhibitors and breast cancer cell killers in the presence of copper.
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Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells.
Di Chen,Kenyon G. Daniel,Marina S. Chen,Deborah J. Kuhn,Kristin R. Landis-Piwowar,Q. Ping Dou +5 more
TL;DR: The flavonoids apigenin, quercetin, kaempferol and myricetin are examined for their proteasome-inhibitory and apoptosis-inducing abilities in human tumor cells and suggested that inhibition of the proteasomes by flavonoid may be one of the mechanisms responsible for their cancer-preventive effects.
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Copper storage diseases: Menkes, Wilsons, and cancer.
TL;DR: The chemical nature and biological roles of copper, Wilsons and Menkes disease and their therapies, and the use of copper related therapies in cancer are examined.
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Green tea and tea polyphenols in cancer prevention
Di Chen,Kenyon G. Daniel,Deborah J. Kuhn,Aslamuzzaman Kazi,Mohammad Bhuiyan,Lian-Hai Li,Zhigang Wang,Sheng Biao Wan,Wai Har Lam,Tak Hang Chan,Q. Ping Dou +10 more
TL;DR: The cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] are widely supported by results from epidemiological, cell culture, animal and clinical studies in the recent decade.