Kerang Zhang

TL;DR: Although staff accessed limited mental healthcare services, distressed staff nonetheless saw these services as important resources to alleviate acute mental health disturbances and improve their physical health perceptions, emphasize the importance of being prepared to support frontline workers through mental health interventions at times of widespread crisis.

TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.

TL;DR: It is found that default mode network functional connectivity remains a prime target for understanding the pathophysiology of depression, with particular relevance to revealing mechanisms of effective treatments, and reduced rather than increased FC within the DMN is found.

TL;DR: Compared with the control group, subjects with MDD and those at high risk for MDD exhibited significantly decreased ReHo in the right insula and in the left cerebellum, suggesting abnormalities in certain brain areas may play an important role in the pathophysiology of depression.

TL;DR: It is demonstrated that changes in the amount of mtDNA and telomere length are consequences of stress and entering a depressed state and have important implications for understanding how stress causes the disease.