Ketevan Pachkoria

TL;DR: Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation, and amoxicillin-clavulanate stands out as the most common drug related to DILI.

TL;DR: Patients with cholestatic/mixed injury were more prone to chronicity than patients with hepatocellular injury, and cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage.

TL;DR: Age is the most important determinant in the biochemical expression of AC hepatotoxicity; younger age is associated with cytolytic damage and shorter treatment duration, whereas cholestatic/mixed type of damage is related to older age and prolonged AC therapy.

TL;DR: The Naranjo Adverse Drug Reactions Probability Scale is a simple and widely used nonspecific scale, which has not been specifically evaluated in drug‐induced liver injury.

TL;DR: IL-10, IL-4 and TNF-alpha genetic polymorphisms were not related to the risk of developing DILI, but low IL-10 producing haplotype is associated with low eOSinophil count, absence of eosinophilia and may be associated with worse clinical outcome from DILi.