K
Kevin Camphausen
Researcher at National Institutes of Health
Publications - 335
Citations - 16574
Kevin Camphausen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Radiation therapy & Radiosensitivity. The author has an hindex of 63, co-authored 314 publications receiving 14893 citations. Previous affiliations of Kevin Camphausen include Harvard University.
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Journal ArticleDOI
Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma
Teri N. Kreisl,Lyndon Kim,Kraig Moore,Paul Duic,Cheryl Royce,Irene Stroud,Nancy Garren,Megan Mackey,John A. Butman,Kevin Camphausen,John W. Park,Paul S. Albert,Howard A. Fine +12 more
TL;DR: It is concluded that single-agent bevacizumab has significant biologic and antiglioma activity in patients with recurrent glioblastoma.
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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric Reits,James W. Hodge,Carla A. Herberts,Tom A.M. Groothuis,Mala Chakraborty,Elizabeth K. Wansley,Kevin Camphausen,Rosalie M. Luiten,Arnold H. de Ru,Joost Neijssen,Alexander Griekspoor,Elly Mesman,Frank A. W. Verreck,Hergen Spits,Jeffrey Schlom,Peter A. van Veelen,Jacques Neefjes +16 more
TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.
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Antiangiogenic and Antitumor Effects of Bevacizumab in Patients With Inflammatory and Locally Advanced Breast Cancer
Suparna Wedam,Jennifer A. Low,Sherry X. Yang,Catherine Chow,Peter L. Choyke,David N. Danforth,Stephen M. Hewitt,Arlene Berman,Seth M. Steinberg,David J. Liewehr,Jonathan Plehn,Arpi Doshi,Dave Thomasson,Nicole J. McCarthy,Hartmut Koeppen,Mark E. Sherman,Jo Anne Zujewski,Kevin Camphausen,Helen Chen,Sandra M. Swain +19 more
TL;DR: Bvacizumab has inhibitory effects on VEGF receptor activation and vascular permeability, and induces apoptosis in tumor cells, and persists with the addition of chemotherapy.
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Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
Mala Chakraborty,Scott I. Abrams,Kevin Camphausen,Kebin Liu,Tamalee Scott,C. Norman Coleman,James W. Hodge +6 more
TL;DR: Results showed for the first time that regulation of the Fas pathway in tumor cells by irradiation plays an important role in their sensitization to Ag-specific CTL; and a combination regimen of tumor-targeted irradiation and CTL promotes more effective antitumor responses in vivo, which may have implications for the combination of immunotherapy and radiation therapy.
Journal ArticleDOI
External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.
Mala Chakraborty,Scott I. Abrams,C. Norman Coleman,Kevin Camphausen,Jeffrey Schlom,James W. Hodge +5 more
TL;DR: A new paradigm for the use of local tumor irradiation in combination with active specific vaccine therapy to elicit durable antitumor responses of established tumors is demonstrated.