K
Kevin G. Becker
Researcher at National Institutes of Health
Publications - 323
Citations - 30594
Kevin G. Becker is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 78, co-authored 313 publications receiving 27832 citations. Previous affiliations of Kevin G. Becker include Vanderbilt University & University of Maryland, Baltimore.
Papers
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J. Pearson,Joseph A. Baur,Kaitlyn N. Lewis,Leonid Peshkin,Nathan L. Price,Nathan L. Price,Nazar Labinskyy,William R. Swindell,Davida Kamara,Robin K. Minor,Evelyn Perez,Hamish A. Jamieson,Yongqing Zhang,Stephen R. Dunn,Kumar Sharma,Nancy Pleshko,Laura A. Woollett,Anna Csiszar,Yuji Ikeno,David G. Le Couteur,Peter J. Elliott,Kevin G. Becker,Plácido Navas,Donald K. Ingram,Norman S. Wolf,Zoltan Ungvari,David A. Sinclair,Rafael de Cabo +27 more
TL;DR: It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Journal ArticleDOI
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo,Evi M. Mercken,Sarah J. Mitchell,Sarah J. Mitchell,Sarah J. Mitchell,Hector H. Palacios,Patricia L. Mote,Morten Scheibye-Knudsen,Ana P. Gomes,Theresa M. Ward,Robin K. Minor,Marie-José Blouin,Matthias Schwab,Michael Pollak,Yongqing Zhang,Yinbing Yu,Kevin G. Becker,Vilhelm A. Bohr,Donald K. Ingram,David A. Sinclair,Norman S. Wolf,Stephen R. Spindler,Michel Bernier,Rafael de Cabo +23 more
TL;DR: It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
Journal ArticleDOI
Analysis of Microarray Data Using Z Score Transformation
TL;DR: It is concluded that the Z score transformation normalization method accompanied by either Z ratios or Z tests for significance estimates offers a useful method for the basic analysis of microarray data.
Journal ArticleDOI
The Genetic Association Database
TL;DR: The development of a genetic association database (GAD) that aims to collect, standardize and archive genetic association study data and to make it easily accessible to the scientific community is described.