K
Kevin Gaston
Researcher at University of Nottingham
Publications - 83
Citations - 2940
Kevin Gaston is an academic researcher from University of Nottingham. The author has contributed to research in topics: Transcription factor & Promoter. The author has an hindex of 29, co-authored 78 publications receiving 2725 citations. Previous affiliations of Kevin Gaston include Lincoln's Inn & Pasteur Institute.
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Journal ArticleDOI
Stringent spacing requirements for transcription activation by CRP.
TL;DR: A model system is constructed in which a consensus CRP binding site is placed at different distances upstream of the melR promoter, indicating that CRP-cAMP activates transcription from these promoters in similar but distinct ways.
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Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription
Andrew I. Bell,Kevin Gaston,Roy Williams,Karen E. Chapman,Annie Kolb,Henri Buc,Stephen D. Minchin,Jackie Williams,Stephen J. W. Busby +8 more
TL;DR: The results suggest that CRP can use different contacts and/or conformations during transcription activation at promoters with different architectures, and is totally inactive with respect to the activation of transcription from the promoter carrying the CRP site at -61.5.
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The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.
TL;DR: The data suggest that neither the DNA binding activity of E2 nor other HPV proteins are required for the induction of apoptosis by E2 and that E2-induced cell death occurs via a p53-dependent pathway.
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Transcriptional repression in eukaryotes: repressors and repression mechanisms.
Kevin Gaston,P.S. Jayaraman +1 more
TL;DR: The mechanisms by which transcriptional repression is achieved and the role that chromatin re-organisation plays in this process are discussed.
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The regulation of cell proliferation by the papillomavirus early proteins.
TL;DR: Evidence is outlined that suggests a role for E2 in the regulation of cell proliferation, and the importance of this regulation in viral infection and cervical tumourigenesis is discussed.