K
Kevin M. Brindle
Researcher at University of Cambridge
Publications - 314
Citations - 22755
Kevin M. Brindle is an academic researcher from University of Cambridge. The author has contributed to research in topics: In vivo & Magnetic resonance imaging. The author has an hindex of 70, co-authored 296 publications receiving 19633 citations. Previous affiliations of Kevin M. Brindle include Laboratory of Molecular Biology & Cancer Research UK.
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Journal ArticleDOI
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
Léonie M. Raamsdonk,Bas Teusink,David Broadhurst,Nianshu Zhang,Andrew Hayes,Michael C. Walsh,Jan A. Berden,Kevin M. Brindle,Douglas B. Kell,Jem J. Rowland,Hans V. Westerhoff,Karel van Dam,Stephen G. Oliver +12 more
TL;DR: It is demonstrated how the intracellular concentrations of metabolites can reveal phenotypes for proteins active in metabolic regulation, and this approach to functional analysis, using comparative metabolomics, is called FANCY—an abbreviation for functional analysis by co-responses in yeast.
Journal ArticleDOI
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.
Sam E. Day,Mikko I. Kettunen,Ferdia A. Gallagher,De-En Hu,Mathilde H. Lerche,Jan Wolber,Klaes Golman,Jan Henrik Ardenkjær-Larsen,Kevin M. Brindle +8 more
TL;DR: In lymphoma-bearing mice injected intravenously with hyperpolarized [1-13C]pyruvate, it is shown that the lactate dehydrogenase–catalyzed flux of 13C label between the carboxyl groups of pyruvates and lactate in the tumor can be measured using 13C magnetic resonance spectroscopy and spectroscopic imaging, and that this flux is inhibited within 24 h of chemotherapy.
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
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Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
Ferdia A. Gallagher,Mikko I. Kettunen,Sam E. Day,De-En Hu,Jan Henrik Ardenkjær-Larsen,René in ‘t Zandt,Pernille Rose Jensen,Magnus Karlsson,Klaes Golman,Mathilde H. Lerche,Kevin M. Brindle +10 more
TL;DR: Tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate and 13CO2 following intravenous injection of hyperPolarized H13CO3-.
Journal ArticleDOI
Imaging biomarker roadmap for cancer studies.
James P B O'Connor,Eric O. Aboagye,Judith E. Adams,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Sally F. Barrington,Ambros J. Beer,Ronald Boellaard,Sarah E. Bohndiek,J. Michael Brady,Gina Brown,David L. Buckley,Thomas L. Chenevert,Laurence P. Clarke,Sandra Collette,Gary Cook,Nandita M. deSouza,John Dickson,Caroline Dive,Jeffrey L. Evelhoch,Corinne Faivre-Finn,Ferdia A. Gallagher,Fiona J. Gilbert,Robert J. Gillies,Vicky Goh,John R. Griffiths,Ashley M. Groves,Steve Halligan,Adrian L. Harris,David J. Hawkes,Otto S. Hoekstra,Erich P. Huang,Brian Hutton,Edward F. Jackson,Gordon C Jayson,Andrew J. I. Jones,Dow-Mu Koh,Denis Lacombe,Philippe Lambin,Nathalie Lassau,Martin O. Leach,Ting-Yim Lee,Edward Leen,Jason S. Lewis,Yan Liu,Mark F. Lythgoe,Prakash Manoharan,Ross J. Maxwell,Kenneth A. Miles,Bruno Morgan,Steve Morris,Tony Ng,Anwar R. Padhani,Geoff J M Parker,Mike Partridge,Arvind P. Pathak,Arvind P. Pathak,Andrew C. Peet,Shonit Punwani,Andrew R. Reynolds,Simon P. Robinson,Lalitha K. Shankar,Ricky A. Sharma,Dmitry Soloviev,Sigrid Stroobants,Daniel C. Sullivan,Stuart A. Taylor,Paul S. Tofts,Gillian M. Tozer,Marcel van Herk,Simon Walker-Samuel,James Wason,Kaye J. Williams,Paul Workman,Thomas E. Yankeelov,Kevin M. Brindle,Lisa M. McShane,Alan Jackson,John C. Waterton +78 more
TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.