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Kevin P. Campbell
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 532
Citations - 63329
Kevin P. Campbell is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Muscular dystrophy & Dystroglycan. The author has an hindex of 137, co-authored 521 publications receiving 60854 citations. Previous affiliations of Kevin P. Campbell include University of Toronto & University of Michigan.
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Journal ArticleDOI
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
Oxana Ibraghimov-Beskrovnaya,James M. Ervasti,Cynthia J. Leveille,Clive A. Slaughter,Suzanne W. Sernett,Kevin P. Campbell +5 more
TL;DR: The hypothesis that the dramatic reduction in the 156K DAG in Duchenne muscular dystrophy leads to a loss of a linkage between the sarcolemma and extra-cellular matrix and that this may render muscle fibres more susceptible to necrosis is supported.
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A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin
TL;DR: The results support a role for the striated muscle dystrophin-glycoprotein complex in linking the actin- based cytoskeleton with the extracellular matrix and suggest that dystophin and dystroglycan may play substantially different functional roles in nonmuscle tissues.
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Membrane organization of the dystrophin-glycoprotein complex
TL;DR: It is demonstrated that dystrophin and its 59 kd associated protein are cytoskeletal elements that are tightly linked to a 156 kd extracellular glycoprotein by way of a complex of transmembrane proteins.
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Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle.
TL;DR: It is shown that four glycoproteins are integral components of the dystrophin complex and that the concentration of one of these is greatly reduced in DMD patients, suggesting the reduction in this glycoprotein may be one of the first stages of the molecular pathogenesis of muscular dystrophy.
Journal ArticleDOI
Defective membrane repair in dysferlin-deficient muscular dystrophy
Dimple Bansal,Katsuya Miyake,Steven S. Vogel,Séverine Groh,Chien-Chang Chen,Roger A. Williamson,Paul L. McNeil,Kevin P. Campbell +7 more
TL;DR: It is shown that disruption of the muscle membrane repair machinery is responsible for dysferlin-deficient muscle degeneration, and the importance of this basic cellular mechanism of membrane resealing in human disease is highlighted.