K
Khalid Iqbal
Researcher at University of York
Publications - 186
Citations - 32924
Khalid Iqbal is an academic researcher from University of York. The author has contributed to research in topics: Hyperphosphorylation & Tau protein. The author has an hindex of 77, co-authored 181 publications receiving 29856 citations.
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Journal ArticleDOI
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
Inge Grundke-Iqbal,Khalid Iqbal,Yunn-Chyn Tung,Maureen Quinlan,Henryk M. Wisniewski,Lester I. Binder +5 more
TL;DR: It is suggested that tau in Alzheimer brain is an abnormally phosphorylated protein component of PHF, the two major locations of paired-helical filaments in Alzheimer disease brain.
Journal ArticleDOI
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
TL;DR: Human brain tau and paired helical filament polypeptides co-migrated on sodium dodecyl sulfate-polyacrylamide gels suggest that tau is a major component of Alzheimer paired helicals filaments.
Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
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Tau pathology in Alzheimer disease and other tauopathies
Khalid Iqbal,Alejandra del C. Alonso,She Chen,M. Omar Chohan,Ezzat El-Akkad,Cheng-Xin Gong,Sabiha Khatoon,Bin Li,Fei Liu,Abdur Rahman,Hitoshi Tanimukai,Inge Grundke-Iqbal +11 more
TL;DR: Inhibition of this tau abnormality is one of the most promising therapeutic approaches to AD and other tauopathies.
Journal ArticleDOI
Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments
TL;DR: It appears that τ self-assembles by association of the microtubule binding domains/repeats and that the abnormal hyperphosphorylation promotes the self-assembly of τ into tangles of PHF and straight filaments by neutralizing the inhibitory basic charges of the flanking regions.