K
Khozirah Shaari
Researcher at Universiti Putra Malaysia
Publications - 238
Citations - 4344
Khozirah Shaari is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Clinacanthus nutans & Biology. The author has an hindex of 30, co-authored 216 publications receiving 3377 citations. Previous affiliations of Khozirah Shaari include Forest Research Institute & Hoshi University.
Papers
More filters
Journal ArticleDOI
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
Harrison J. Hocker,Kwang Jin Cho,Chung Ying K. Chen,Nandini Rambahal,Sreenivasa Rao Sagineedu,Khozirah Shaari,Johnson Stanslas,John F. Hancock,Alemayehu A. Gorfe +8 more
TL;DR: The combined analysis of the computational and cell biology results show that AGP derivatives directly bind Ras, block GDP–GTP exchange, and inhibit both wild-type and oncogenic K-Ras signaling, and demonstrate that inhibiting nucleotide exchange is a valid approach to abrogating the function of onCogenic mutant Ras.
Journal ArticleDOI
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
Ka-Heng Lee,Farida Haryani Ab. Aziz,Ahmad Syahida,Faridah Abas,Khozirah Shaari,Daud Ahmad Israf,Nordin Haji Lajis +6 more
TL;DR: The present results showed that compounds 2, 13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents.
Journal ArticleDOI
Antioxidant, radical-scavenging, anti-inflammatory, cytotoxic and antibacterial activities of methanolic extracts of some Hedyotis species
Rohaya Ahmad,Abdul Manaf Ali,Daud Ahmad Israf,Nor Hadiani Ismail,Khozirah Shaari,Nordin H. Lajis +5 more
TL;DR: The results from the Griess assay showed that the tested extracts are weak inhibitors of NO synthase, however, all tested extracts exhibited moderate cytotoxic properties against CEM-SS cell line giving CD50 values in the range of 21-41 microg/ml.
Journal ArticleDOI
A labdane diterpene glucoside from the rhizomes of Curcuma mangga.
Faridah Abas,Nordin H. Lajis,Khozirah Shaari,Daud Ahmad Israf,Johnson Stanslas,Umi Kalsom Yusuf,Salahuddin Mohd Raof +6 more
TL;DR: A new labdane diterpene glucoside, curcumanggosides, together with nine known compounds, including labda-8(17),12-diene-15,16-dial, and scopoletin showed significant antioxidant activity and Zerumin B, demethoxycurcumin, bisdemethoxyCurcumin and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.
Journal ArticleDOI
Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood
Syahida Ahmad,Daud Ahmad Israf,Nordin H. Lajis,Khozirah Shaari,Habsah Mohamed,Afiza A. Wahab,Khaizurin T. Ariffin,Wei Yee Hoo,Nasaruddin Abdul Aziz,Arifah Abdul Kadir,Mohamad R. Sulaiman,Muhammad Nazrul Somchit +11 more
TL;DR: The results suggest that cardamonin acts upon major pro-inflammatory mediators in a similar fashion as described by previous work on other closely related synthetic hydroxychalcones and strengthens the conclusion of the importance of the methoxyl moiety substitution on the 4' or 6' locations of the A benzene ring.